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Expression of CYP3A in the human liver--evidence that the shift between CYP3A7 and CYP3A4 occurs immediately after birth.
TLDR
Data supports the assumption that CYP3A4 expression is transcriptionally activated during the first week after birth and is accompanied by a simultaneous decrease of CYP2A7 expression, in such a way that the overall CYP 3A protein content and the level of pentoxyresorufin dealkylase catalyzed by the two proteins remain nearly constant.
Metabolism of irinotecan (CPT-11) by CYP3A4 and CYP3A5 in humans.
TLDR
CYP3A plays a major role in the metabolism of CPT-11, with some differences of the metabolic profile exhibited by 3A4 and 3A5, indicating that C PT-11 is preferentially metabolized by CYP3A4.
Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation.
TLDR
Microsomes from patients treated with barbiturates and benzodiazepines increased the formation of metabolite M4 to the level of metabolites M5, demonstrating that drug interactions could modify the human metabolism of taxol.
CYP2D6- and CYP3A-dependent metabolism of dextromethorphan in humans.
TLDR
The data suggest that the N-demethylation of dextromethorphan is dependent on CYP3A and that both CYP2D6 and CYP 3A are involved in the overall metabolism of deXTromethmorphan.
Expression of CYP2D6 in developing human liver.
TLDR
The rise in CYP2D6 protein was associated with the developmental onset of dextromethorphan O-dem methylation, but not N-demethylation, even if activity was lower in fetal than in neonatal and in adult liver microsomes, suggesting that regulation is primarily at the transcriptional level, but cannot rule out the participation of post-transcriptional events in the regulation process throughout ontogenesis.
Identification of human cytochrome P450s involved in the formation of all-trans-retinoic acid principal metabolites.
TLDR
Several human P450s involved in atRA metabolism have been identified, and the expression of which was shown to direct at RA metabolism toward the formation of specific metabolites, including 4-OH-RA and 4-oxo-RA.
Regioselective metabolism of taxoids by human CYP3A4 and 2C8: structure-activity relationship.
TLDR
Data strongly suggested that the structure of the lateral chain and the nature of substituent in position 10 play an important role in determining the regioselective oxidation by P450 proteins and modulate the reaction rate by human liver microsomes.
Developmental expression of CYP2C and CYP2C-dependent activities in the human liver: in-vivo/in-vitro correlation and inducibility.
TLDR
The hepatic content in CYP2C8, 2C9 and 2C18 RNA displayed the same profile of evolution, which suggested a coregulation of their synthesis during the neonatal period, enabling dating of the onset of CYP1C proteins to the first weeks after birth, which is of considerable clinical importance in pediatric pharmacology.
A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities.
TLDR
The purpose of the proposed nomenclature is to provide for the unambiguous identification of orthologous forms of mammalian FMOs, regardless of the species or tissue in question.
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