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Colonic metabolism of dietary polyphenols: influence of structure on microbial fermentation products.
TLDR
The results support extensive metabolism of dietary polyphenols in the colon, depending on substrate concentration and residence time, with resultant formation of simple phenolics, which can be considered biomarkers of colonic metabolism if subsequently absorbed. Expand
The metabolic fate of dietary polyphenols in humans.
TLDR
The results show that the majority of the in vivo forms derive from cleavage products of the action of colonic bacterial enzymes and subsequent metabolism in the liver, and suggest that consideration should be given to the cleavage Products as having a putative role as physiologically relevant bioactive components in vivo. Expand
Novel biomarkers of the metabolism of caffeic acid derivatives in vivo.
TLDR
The results reveal isoferulic acid (and possibly dihydroferulic acid) as novel markers of caffeoyl quinic acid metabolism and shows a highly significant excretion increase postsupplementation. Expand
Uptake and metabolism of epicatechin and its access to the brain after oral ingestion.
TLDR
The presence of the epicatechin glucuronide and 3'-O-methyl epicatechine glucuronides formed after oral ingestion formed in the rat brain tissue is reported. Expand
Assessment of clopidogrel non-response by the PFA-100® system using the new test cartridge INNOVANCE® PFA P2Y
Until now, the PFA-100® system has been considered unsuitable for monitoring clopidogrel efficacy. The authors evaluated platelet function in peripheral arterial occlusive disease (PAOD) patientsExpand
The Metabolism of Dietary Polyphenols and the Relevance to Circulating Levels of Conjugated Metabolites
TLDR
The bioavailability, metabolism and elimination of polyphenols from blackcurrant juice, rich in anthocyanins, flavonols, and hydroxycinnamates, were investigated and most significantly, of the hydroxydynamic acids, conjugated and free ferulic, isoferulic, p -coumaric, sinapic and vanillic acids were identified in plasma and urine, using GC-MS techniques. Expand
Black Tea Represents a Major Source of Dietary Phenolics Among Regular Tea Drinkers
TLDR
Black tea can be considered to be a rich source of polyphenols and/or antioxidants and the antioxidant activity of black tea preparations is higher than that of most reported dietary agents on a daily basis. Expand
Anthocyanins and colonic metabolites of dietary polyphenols inhibit platelet function.
TLDR
Results show that anthocyanins and in vivo metabolites of polyphenols have anti-thrombotic properties, suggesting themselves as well as their dietary sources and precursors as potential cardiovascular health promoters. Expand
Bioavailability of flavan-3-ols and procyanidins: gastrointestinal tract influences and their relevance to bioactive forms in vivo.
TLDR
Studies suggest that the major bioactive forms of flavan-3-ols in vivo are likely to be metabolites and/or conjugates of epicatechin, one such metabolite shown to exert protective effects against oxidative stress-induced cell death. Expand
Caffeic acid derivatives in artichoke extract are metabolised to phenolic acids in vivo
TLDR
The caffeic acid esters found in the artichoke extract capsule are absorbed, metabolised and excreted as methylated phenolic acids such as ferulic, isoferulic, dihydroferulic and vanillic acid. Expand
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