Memantine

Known as: 1-Amino-3,5-dimethyladamantane, 3,5-Dimethyl-1-adamantanamine, 3,5-Dimethyl-1-aminoadamantane 
AMANTADINE derivative that has some dopaminergic effects. It has been proposed as an antiparkinson agent.
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Alzheimer’s disease (AD) is a major form of senile dementia, characterized by progressive memory and neuronal loss combined with… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND Clinical trials have shown the benefits of cholinesterase inhibitors for the treatment of mild-to-moderate Alzheimer's… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are common forms of dementia that substantially… (More)
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Review
2005
Review
2005
BACKGROUND Memantine, a low affinity antagonist to glutamate NMDA receptors, may prevent excitatory neurotoxicity in dementia… (More)
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Highly Cited
2004
Highly Cited
2004
CONTEXT Memantine is a low- to moderate-affinity, uncompetitive N-methyl-D-aspartate receptor antagonist. Controlled trials have… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Overstimulation of the N-methyl-D-aspartate (NMDA) receptor by glutamate is implicated in neurodegenerative disorders… (More)
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Highly Cited
2003
Highly Cited
2003
 
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Highly Cited
1999
Highly Cited
1999
OBJECTIVES To assess clinical efficacy and safety of memantine--an uncompetitive N-methyl-D-aspartate (NMDA) antagonist--in… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE It is well known that acute exposure to high concentrations of glutamate is toxic to central mammalian neurons. However… (More)
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Highly Cited
1992
Highly Cited
1992
Excessive activation of NMDA receptors is thought to mediate the calcium-dependent neurotoxicity associated with hypoxic-ischemic… (More)
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