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Amantadine

Known as: 1-aminoadamantane, 1-adamantylamine, Tricyclo[3.3.1.1(3,7)]decan-1-amine 
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (23)

2-aminoadamantane4-bromobenzoyl-methyladamantylamineAmanAmanta

Broader (6)

AdamantaneAnalgesics, Non-NarcoticAntibioticsAntiparkinson Agents
Amantadine HydrochlorideAmantadine Hydrochloride 10 MG/ML Oral SolutionAmantadine SulfateAmantadine:Susc:Pt:Isolate:OrdQn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers
The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine… 
Highly Cited
2006
Highly Cited
2006
Prevention and Control of Influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP).
This report updates the 2005 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of… 
Highly Cited
2000
Highly Cited
2000
Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza
ContextPrevious studies have shown oseltamivir, a neuraminidase inhibitor, to be effective in preventing influenza and treating… 
Highly Cited
1998
Highly Cited
1998
Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
Objective: To determine the effects of the N-methyl-D-aspartate (NMDA) antagonist amantadine on levodopa-associated dyskinesias… 
Highly Cited
1998
Highly Cited
1998
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
Recently, we cloned the human cation transporter hOCT2, a member of a new family of polyspecific transporters from kidney, and… 
Review
1994
Review
1994
Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.
The pharmacological inhibition of excitatory amino acid neurotransmission has evolved to be a major topic in neuropharmacology… 
Highly Cited
1993
Highly Cited
1993
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine… 
Highly Cited
1985
Highly Cited
1985
The molecular basis of the specific anti‐influenza action of amantadine.
Amantadine (1‐aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infections. In tissue… 
Highly Cited
1982
Highly Cited
1982
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.
Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of… 
Highly Cited
1964
Highly Cited
1964
Antiviral Activity of 1-Adamantanamine (Amantadine)
I-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture… 
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