Amantadine

Known as: 1-aminoadamantane, 1-adamantylamine, Tricyclo[3.3.1.1(3,7)]decan-1-amine 
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect… (More)

Topic mentions per year

Topic mentions per year

1964-2018
05010019642018

Papers overview

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Review
2014
Review
2014
New human influenza A virus strains regularly emerge causing seasonal epidemics and occasional pandemics. Lately, several… (More)
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Highly Cited
2006
Highly Cited
2006
We examined the distribution of genetic mutations associated with resistance to the M2 ion channel-blocking adamantane… (More)
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Highly Cited
2004
Highly Cited
2004
This report updates, expands, and replaces the previously published CDC "Guideline for Prevention of Nosocomial Pneumonia". The… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Oseltamivir is an effective inhibitor of influenza virus neuraminidase. Although viruses resistant to oseltamivir… (More)
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Highly Cited
2003
Highly Cited
2003
Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new drug targets especially important. HCV… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To determine the effects of the N-methyl-D-aspartate (NMDA) antagonist amantadine on levodopa-associated dyskinesias… (More)
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Highly Cited
1993
Highly Cited
1993
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine… (More)
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Highly Cited
1992
Highly Cited
1992
The influenza virus M2 protein was expressed in Xenopus laevis oocytes and shown to have an associated ion channel activity… (More)
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Highly Cited
1985
Highly Cited
1985
Amantadine (1-aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infections. In tissue… (More)
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Highly Cited
1964
Highly Cited
1964
I-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture… (More)
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