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Amantadine

Known as: 1-aminoadamantane, 1-adamantylamine, Tricyclo[3.3.1.1(3,7)]decan-1-amine 
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect… Expand
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine… Expand
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Highly Cited
2006
Highly Cited
2006
This report updates the 2005 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of… Expand
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Highly Cited
2003
Highly Cited
2003
Hepatitis C virus (HCV) cannot be grown in vitro, making biochemical identification of new drug targets especially important. HCV… Expand
Highly Cited
2000
Highly Cited
2000
ContextPrevious studies have shown oseltamivir, a neuraminidase inhibitor, to be effective in preventing influenza and treating… Expand
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Highly Cited
1998
Highly Cited
1998
Objective: To determine the effects of the N-methyl-D-aspartate (NMDA) antagonist amantadine on levodopa-associated dyskinesias… Expand
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Highly Cited
1998
Highly Cited
1998
Recently, we cloned the human cation transporter hOCT2, a member of a new family of polyspecific transporters from kidney, and… Expand
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Review
1994
Review
1994
The pharmacological inhibition of excitatory amino acid neurotransmission has evolved to be a major topic in neuropharmacology… Expand
Highly Cited
1993
Highly Cited
1993
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine… Expand
Highly Cited
1985
Highly Cited
1985
Amantadine (1‐aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infections. In tissue… Expand
Highly Cited
1964
Highly Cited
1964
I-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture… Expand