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Amantadine
Known as:
1-aminoadamantane
, 1-adamantylamine
, Tricyclo[3.3.1.1(3,7)]decan-1-amine
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A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect…
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National Institutes of Health
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Related topics
Related topics
43 relations
Narrower (23)
2-aminoadamantane
4-bromobenzoyl-methyladamantylamine
Aman
Amanta
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Broader (6)
Adamantane
Analgesics, Non-Narcotic
Antibiotics
Antiparkinson Agents
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Amantadine Hydrochloride
Amantadine Hydrochloride 10 MG/ML Oral Solution
Amantadine Sulfate
Amantadine:Susc:Pt:Isolate:OrdQn
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers
S. Cady
,
K. Schmidt-Rohr
,
Jun Wang
,
Cinque S. Soto
,
W. DeGrado
,
M. Hong
Nature
2010
Corpus ID: 4373681
The M2 protein of influenza A virus is a membrane-spanning tetrameric proton channel targeted by the antiviral drugs amantadine…
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Highly Cited
2006
Highly Cited
2006
Prevention and Control of Influenza: recommendations of the Advisory Committee on Immunization Practices (ACIP).
Nicole M Smith
,
J. Bresee
,
D. Shay
,
T. Uyeki
,
N. Cox
,
R. Strikas
MMWR Recommendations and Reports
2006
Corpus ID: 24801375
This report updates the 2005 recommendations by the Advisory Committee on Immunization Practices (ACIP) regarding the use of…
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Highly Cited
2000
Highly Cited
2000
Efficacy and Safety of the Oral Neuraminidase Inhibitor Oseltamivir in Treating Acute Influenza
J. Treanor
,
F. Hayden
,
+7 authors
R. Mills
2000
Corpus ID: 34735483
ContextPrevious studies have shown oseltamivir, a neuraminidase inhibitor, to be effective in preventing influenza and treating…
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Highly Cited
1998
Highly Cited
1998
Amantadine as treatment for dyskinesias and motor fluctuations in Parkinson's disease
L. Metman
,
P. Del Dotto
,
P. van den Munckhof
,
J. Fang
,
M. Mouradian
,
T. Chase
Neurology
1998
Corpus ID: 7139620
Objective: To determine the effects of the N-methyl-D-aspartate (NMDA) antagonist amantadine on levodopa-associated dyskinesias…
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Highly Cited
1998
Highly Cited
1998
Human neurons express the polyspecific cation transporter hOCT2, which translocates monoamine neurotransmitters, amantadine, and memantine.
A. Busch
,
U. Karbach
,
+10 authors
H. Koepsell
Molecular Pharmacology
1998
Corpus ID: 33008868
Recently, we cloned the human cation transporter hOCT2, a member of a new family of polyspecific transporters from kidney, and…
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Review
1994
Review
1994
Amantadine and memantine are NMDA receptor antagonists with neuroprotective properties.
J. Kornhuber
,
M. Weller
,
K. Schoppmeyer
,
P. Riederer
Journal of neural transmission. Supplementum
1994
Corpus ID: 46494882
The pharmacological inhibition of excitatory amino acid neurotransmission has evolved to be a major topic in neuropharmacology…
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Highly Cited
1993
Highly Cited
1993
Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block
C. Wang
,
K. Takeuchi
,
L. Pinto
,
R. Lamb
Journal of Virology
1993
Corpus ID: 41037804
The influenza A virus M2 integral membrane protein has ion channel activity which can be blocked by the antiviral drug amantadine…
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Highly Cited
1985
Highly Cited
1985
The molecular basis of the specific anti‐influenza action of amantadine.
A. Hay
,
A. Wolstenholme
,
J. Skehel
,
M. Smith
EMBO Journal
1985
Corpus ID: 38423512
Amantadine (1‐aminoadamantane hydrochloride) is effective in the prophylaxis and treatment of influenza A infections. In tissue…
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Highly Cited
1982
Highly Cited
1982
A controlled trial of amantadine and rimantadine in the prophylaxis of influenza A infection.
R. Dolin
,
R. Reichman
,
H. Madore
,
R. Maynard
,
P. N. Linton
,
J. Webber-Jones
New England Journal of Medicine
1982
Corpus ID: 38916177
Four hundred fifty volunteers participated in a placebo-controlled, double-blind, randomized trial of the prophylactic effects of…
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Highly Cited
1964
Highly Cited
1964
Antiviral Activity of 1-Adamantanamine (Amantadine)
W. Davies
,
R. Grunert
,
+7 authors
C. E. Hoffmann
Science
1964
Corpus ID: 32237492
I-Adamantanamine (amantadine) causes a selective, reproducible, dose-related inhibition of influenza infections in tissue culture…
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