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Amantadine

Known as: 1-aminoadamantane, 1-adamantylamine, Tricyclo[3.3.1.1(3,7)]decan-1-amine 
A synthetic tricyclic amine with antiviral, antiparkinsonian, and antihyperalgesic activities. Amantadine appears to exert its antiviral effect… 
National Institutes of Health

Related topics

Related topics

43 relations

Narrower (24)

2-aminoadamantane4-bromobenzoyl-methyladamantylamineAmanAmanta

Broader (6)

AdamantaneAnalgesics, Non-NarcoticAntibioticsAntiparkinson Agents
Amantadine HydrochlorideAmantadine SulfateAmantadine:Susc:Pt:Isolate:OrdQnDrug Allergy

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Long‐term antidyskinetic efficacy of amantadine in Parkinson's disease
Several randomized placebo‐controlled trials have consistently shown antidyskinetic effects of amantadine in levodopa treated… 
Highly Cited
2010
Highly Cited
2010
Recognition-Mediated Activation of Therapeutic Gold Nanoparticles Inside Living Cells
Supramolecular chemistry provides a versatile tool for the organization of molecular systems into functional structures and the… 
Highly Cited
2008
Highly Cited
2008
Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel
Influenza A and B viruses contain proton-selective ion channels, A/M2 and BM2, respectively, and the A/M2 channel activity is… 
Highly Cited
2005
Highly Cited
2005
Amantadine Inhibits NMDA Receptors by Accelerating Channel Closure during Channel Block
The channel of NMDA receptors is blocked by a wide variety of drugs. NMDA receptor channel blockers include drugs of abuse that… 
Highly Cited
2005
Highly Cited
2005
Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: a retrospective autopsy study
Highly Cited
2000
Highly Cited
2000
Beneficial effects of amantadine on L‐dopa‐induced dyskinesias in Parkinson's disease
L‐Dopa‐induced dyskinesias constitute a challenge to the management of advanced Parkinson's disease. According to recent reports… 
Highly Cited
1997
Highly Cited
1997
Trapping channel block of NMDA-activated responses by amantadine and memantine.
We investigated the mechanisms by which the antiparkinsonian and neuroprotective agents amantadine and memantine inhibit… 
Review
1997
Review
1997
Aminoadamantanes as NMDA receptor antagonists and antiparkinsonian agents — preclinical studies
Highly Cited
1995
Highly Cited
1995
Comparison of the potency, kinetics and voltage-dependency of a series of uncompetitive NMDA receptor antagonists in vitro with anticonvulsive and motor impairment activity in vivo
Highly Cited
1995
Highly Cited
1995
Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue.
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