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Optimistic analyses: judicious and swift application of NIs, vaccine and hygiene to an outbreak epicentre, most likely in South-East Asia, could break the chain of transmission.
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Inf influenza infection studies in healthy volunteers with no detectable antibodies to the challenge viruses H3N2 or H1N1 are conducted, finding a large increase in influenza-specific T cell responses by day 7, when virus was completely cleared from nasal samples and serum antibodies were still undetectable.
Viral load drives disease in humans experimentally infected with respiratory syncytial virus.
- J. Devincenzo, T. Wilkinson, Rob Lambkin-Williams
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 15 November 2010
Viral load appears to drive disease manifestations in humans with RSV infection, and the observed parallel viral and disease kinetics support a potential clinical benefit of RSV antivirals and facilitates the development of future RSV therapeutics.
The burden of influenza B: a structured literature review.
- W. Paul Glezen, J. Schmier, C. Kuehn, Kellie J Ryan, J. Oxford
- MedicineAmerican journal of public health
- 6 February 2013
The medical literature demonstrates that influenza B can pose a significant burden to the global population and additional data regarding the incidence, clinical burden, and economic impact of influenza B would augment the understanding of the disease and assist in vaccine development.
Determinants of immunity to influenza infection in man.
The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo.
Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans
- P. Lillie, T. Berthoud, S. Gilbert
- Medicine, BiologyClinical infectious diseases : an official…
- 22 March 2012
A single vaccination with MVA-NP+M1 boosts T-cell responses to conserved influenza antigens in humans and protects against influenza disease and virus shedding in a challenge study.
An early humoral immune response in peripheral blood following parenteral inactivated influenza vaccination.
Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study
- W. Irving, D. James, M. Zambon
- MedicineBJOG : an international journal of obstetrics and…
- 1 October 2000
Whether maternal influenza virus infection in the second and third trimesters of pregnancy results in transplacental transmission of infection, maternal auto‐antibody production or an increase in complications of pregnancy is investigated.