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For the first time in human history virologists have the knowledge about the avian origin of pandemic influenza A viruses. Furthermore, in the last two decades a new class of anti influenza drugs,… Expand
Preexisting influenza-specific CD4+ T cells correlate with disease protection against influenza challenge in humans
Protective immunity against influenza virus infection is mediated by neutralizing antibodies, but the precise role of T cells in human influenza immunity is uncertain. We conducted influenza… Expand
The burden of influenza B: a structured literature review.
- W. Paul Glezen, J. Schmier, C. Kuehn, Kellie J Ryan, J. Oxford
- American journal of public health
- 6 February 2013
We reviewed the epidemiology, clinical characteristics, disease severity, and economic burden of influenza B as reported in the peer-reviewed published literature. We used MEDLINE to perform a… Expand
Effectiveness of oseltamivir in preventing influenza in household contacts: a randomized controlled trial.
CONTEXT Influenza virus is easily spread among the household contacts of an infected person, and prevention of influenza in household contacts can control spread of influenza in the community. … Expand
The H274Y mutation in the influenza A/H1N1 neuraminidase active site following oseltamivir phosphate treatment leave virus severely compromised both in vitro and in vivo.
Oseltamivir carboxylate is a potent and specific inhibitor of influenza A and B neuraminidase (NA). Oseltamivir phosphate, the ethyl ester prodrug of oseltamivir carboxylate, is the first orally… Expand
An early humoral immune response in peripheral blood following parenteral inactivated influenza vaccination.
The enzyme-linked immunospot assay was used to examine the humoral immune response in 15 healthy volunteers immunized with either split or subunit inactivated trivalent influenza vaccine containing… Expand
Determinants of immunity to influenza infection in man.
Influenza virus infection in the second and third trimesters of pregnancy: a clinical and seroepidemiological study
- W. Irving, D. James, +7 authors M. Zambon
- BJOG : an international journal of obstetrics and…
- 1 October 2000
Objective To determine whether maternal influenza virus infection in the second and third trimesters of pregnancy results in transplacental transmission of infection, maternal auto‐antibody… Expand
Structural changes in the haemagglutinin which accompany egg adaptation of an influenza A(H1N1) virus.
Antigenic changes are often induced in the haemagglutinin (HA) of human isolates of influenza A(H1N1) and B viruses during their isolation and propagation in embryonated hens' eggs. In this report we… Expand