• Publications
  • Influence
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
TLDR
The results suggest that nicotinic receptors in the somatodendritic region may be of greater importance than those located in the terminal area for the stimulatory action of systemic NIC on the mesolimbic DA system and support the notion that the meslimbic dopaminergic system is phasically rather than tonically regulated by nicotinics receptor activation within the VTA. Expand
Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
TLDR
A hierarchical control of dopaminergic neuron firing patterns by nAChRs is suggested: activation of beta2*-nAChR switches cells from a resting to an excited state, whereas activation of alpha7*-magnifying lens finely tunes the latter state but only once beta2-n AChRs have been activated. Expand
Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo
TLDR
The data suggest that burst‐firing of midbrain dopamine neurons in vivo results from the tonic activation of NMDA receptors by endogenous excitatory amino acids, a major physiological substrate in the control of the dopamine level in target areas. Expand
Nicotinic effects on the firing pattern of midbrain dopamine neurons.
TLDR
Observations indicate the existence of a nicotinic input, specifically regulating the firing pattern of these central DA cells, in the midbrain dopamine systems of the rat, and may be significant for its behavioural stimulant action. Expand
Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo
TLDR
This selective modulation of the dynamic activity of mesolimbic dopamine neurons by the prefrontal cortex might be important in motivation, learning and schizophrenia. Expand
Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of α7 nicotinic receptors in the ventral tegmental area
TLDR
It is suggested that alpha7 nicotinic receptors in the ventral tegmental area are involved in the acute effect of nicotine on dopamine release in the nucleus accumbens and concluded that the mechanism, by which nicotine stimulates the mesolimbic dopaminergic system, may be an essential constituent of the natural reward-related circuits in brain. Expand
Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release.
TLDR
The results support the notion that nicotinic receptors in the ventral tegmental area may be of greater importance than those located in the nucleus accumbens for mediating some of the stimulatory effects of nicotine on the reward-related mesoaccumbens dopamine system. Expand
Condition‐independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat
TLDR
Behavioral sensitization after chronic NIC treatment is accompanied by an enhanced dopamine release specifically within the PFC, a phenomenon that may be highly significant for the dependence‐producing effects of NIC, particularly in association with major psychiatric disorder, such as schizophrenia. Expand
Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
TLDR
This review examines the role of dopamine in regulating cellular and circuit function within prefrontal cortex in order to understand the significance of the dopamine dysregulation found in schizophrenia and related non-human primate models. Expand
Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome
TLDR
The decreased DA output in the NAC in animals displaying nicotine withdrawal signs is similar to that seen after withdrawal of several other drugs of abuse, and may have bearing on motivational deficits associated with the abstinence reactions. Expand
...
1
2
3
4
5
...