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Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
Stimulation of the mesolimbic dopamine (DA) system is considered of major importance for the rewarding and dependence producing properties of nicotine (NIC). To identify the site of this stimulatoryExpand
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Hierarchical Control of Dopamine Neuron-Firing Patterns by Nicotinic Receptors
Nicotine elicits dopamine release by stimulating nicotinic acetylcholine receptors (nAChRs) on dopaminergic neurons. However, a modulation of these neurons by endogenous acetylcholine has not beenExpand
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Tonic Activation of NMDA Receptors Causes Spontaneous Burst Discharge of Rat Midbrain Dopamine Neurons In Vivo
Midbrain dopamine neurons in vivo discharge in a single‐spike firing pattern or in a burst‐firing pattern. Such activity in vivo strikingly contrasts with the pacemaker activity of the same dopamineExpand
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Nicotinic effects on the firing pattern of midbrain dopamine neurons.
The effects of systemic administration of nicotine or the nicotinic antagonist mecamylamine on the midbrain dopamine (DA) systems of the rat were studied with single cell recording techniques.Expand
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Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo
The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized maleExpand
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Nicotine and food induced dopamine release in the nucleus accumbens of the rat: Putative role of α7 nicotinic receptors in the ventral tegmental area
We have recently shown that the stimulatory effect of nicotine on dopamine output in the nucleus accumbens is largely dependent upon an enhanced glutamate transmission via N-methyl-D-aspartateExpand
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Infusion of nicotine in the ventral tegmental area or the nucleus accumbens of the rat differentially affects accumbal dopamine release.
The present study examined the effects of acute, continuous infusion of nicotine in either the ventral tegmental area or the nucleus accumbens on extracellular concentrations of dopamine in theExpand
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Condition‐independent sensitization of locomotor stimulation and mesocortical dopamine release following chronic nicotine treatment in the rat
Chronic nicotine (NIC) pretreatment has been shown to enhance NIC‐induced locomotor stimulation, an effect that seems critically dependent on activation of brain dopamine (DA) systems. In the presentExpand
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Targeting the dopamine D1 receptor in schizophrenia: insights for cognitive dysfunction
Background and rationaleReinstatement of the function of working memory, the cardinal cognitive process essential for human reasoning and judgment, is potentially the most intractable problem for theExpand
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Reduced dopamine output in the nucleus accumbens but not in the medial prefrontal cortex in rats displaying a mecamylamine-precipitated nicotine withdrawal syndrome
Mesolimbocortical dopamine (DA) neurotransmission is important in the mediation of the dependence-producing actions of nicotine and other drugs of abuse. Withdrawal from chronic treatment withExpand
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