Adamantane

Known as: Adamantane [Chemical/Ingredient], Diamantane, Tricyclo(3.3.1.1(3,7))decane 
A tricyclo bridged hydrocarbon.
National Institutes of Health

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1,3-adamantanedicarboxylic acid1-amino-3-ethyladamantane2-(1-adamantyl)benzimidazole2-(1-adamantyl)imidazole
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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

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2015
2015
Adamantane-Resistant Influenza A Viruses in the World (1902–2013): Frequency and Distribution of M2 Gene Mutations
Adamantanes (amantadine and rimantadine) have been used to prevent and treat influenza A virus infections for many years; however… (More)
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Highly Cited
2011
Highly Cited
2011
Small molecule inhibitors reveal Niemann-Pick C1 is essential for ebolavirus infection
Ebola virus (EboV) is a highly pathogenic enveloped virus that causes outbreaks of zoonotic infection in Africa. The clinical… (More)
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2009
2009
The origin and global emergence of adamantane resistant A/H3N2 influenza viruses.
Resistance to the adamantane class of antiviral drugs by human A/H3N2 influenza viruses currently exceeds 90% in the United… (More)
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Highly Cited
2007
Highly Cited
2007
Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide.
Our previous reports demonstrated an alarming increase in resistance to adamantanes among influenza A(H3N2) viruses isolated in… (More)
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Highly Cited
2007
Highly Cited
2007
The genesis and spread of reassortment human influenza A/H3N2 viruses conferring adamantane resistance.
A dramatic rise in the frequency of resistance to adamantane drugs by influenza A (H3N2) viruses has occurred in recent years… (More)
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Highly Cited
2007
Highly Cited
2007
Susceptibility of highly pathogenic A(H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes.
Since 2003, highly pathogenic A(H5N1) influenza viruses have been the cause of large-scale death in poultry and the subsequent… (More)
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Highly Cited
2006
Highly Cited
2006
Adamantane resistance among influenza A viruses isolated early during the 2005-2006 influenza season in the United States.
CONTEXT The adamantanes, amantadine and rimantadine, have been used as first-choice antiviral drugs against community outbreaks… (More)
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Highly Cited
2005
Highly Cited
2005
Incidence of adamantane resistance among influenza A (H3N2) viruses isolated worldwide from 1994 to 2005: a cause for concern
BACKGROUND Adamantanes have been used to treat influenza A virus infections for many years. Studies have shown a low incidence of… (More)
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Highly Cited
1997
Highly Cited
1997
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.
1. The effects of two adamantane derivatives, 1-trimethylammonio-5-(1-adamantane-methyl-ammoniopentane dibromide) (IEM-1460) and… (More)
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Highly Cited
1991
Highly Cited
1991
Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel: a human postmortem brain study.
Recent studies from our laboratory have provided evidence that the 1-amino-adamantane derivative memantine (1-amino-3,5-dimethyl… (More)
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