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Major Groove

One of the two types of grooves found in a right-handed double helix, running between the sugar phosphate backbones of each strand.
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
TAL (transcription activator-like) effectors, secreted by phytopathogenic bacteria, recognize host DNA sequences through a… Expand
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Highly Cited
2007
Highly Cited
2007
The recognition of specific DNA-binding sites by transcription factors is a critical yet poorly understood step in the control of… Expand
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Highly Cited
2003
Highly Cited
2003
Various chemical modifications were created in short-interfering RNAs (siRNAs) to determine the biochemical properties required… Expand
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Highly Cited
2000
Highly Cited
2000
The double-stranded RNA-binding domain (dsRBD) is a common RNA-binding motif found in many proteins involved in RNA maturation… Expand
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Highly Cited
1999
Highly Cited
1999
The ecteinascidins (Ets), which are natural products derived from marine tunicates, exhibit potent antitumor activity. Of the… Expand
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Highly Cited
1998
Highly Cited
1998
The Smad family of proteins, which are frequently targeted by tumorigenic mutations in cancer, mediate TGF-beta signaling from… Expand
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Highly Cited
1996
Highly Cited
1996
The solution structure of a human immunodeficiency virus type-1 (HIV-1) Rev peptide bound to stem-loop IIB of the Rev response… Expand
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Highly Cited
1993
Highly Cited
1993
Hypoxia-inducible factor 1 (HIF-1) is a DNA binding activity detected in nuclear extracts from Hep3B cells cultured in 1% O2 but… Expand
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Highly Cited
1993
Highly Cited
1993
The 2.5 Å crystal structure of a TATA-box complex with yeast TBP shows that the eight base pairs of the TATA box bind to the… Expand
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Highly Cited
1991
Highly Cited
1991
The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30… Expand
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