• Publications
  • Influence
The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The crystal structure of the large ribosomal subunit from Haloarcula marismortui is determined at 2.4 angstrom resolution, and it includes 2833 of the subunit's 3045 nucleotides and 27 of its 31 proteins. Expand
The structural basis of ribosome activity in peptide bond synthesis.
It is established that the ribosome is a ribozyme and the catalytic properties of its all-RNA active site are addressed and the mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases. Expand
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of AIDS, reveals an asymmetric dimer. TheExpand
Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.
The next generation of autonomous vehicles will be able to communicate with each other in a much more efficient and efficient manner than the current generation of vehicles that can communicate solely with the human eye. Expand
The structure of the E. coli recA protein monomer and polymer
The crystal structure of the recA protein from Escherichia coli at 2.3-Å resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the NExpand
Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees
The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. ThisExpand
Structure of the replicating complex of a pol alpha family DNA polymerase.
This ternary complex structure in the human DNA polymerase alpha family shows a 60 degrees rotation of the fingers domain relative to the apo-protein structure, similar to the fingers movement in pol I family polymerases. Expand
An induced-fit mechanism to promote peptide bond formation and exclude hydrolysis of peptidyl-tRNA
Three new structures of the large ribosomal subunit of Haloarcula marismortui (Hma) complexed with peptidyl transferase substrate analogues are described that reveal an induced-fit mechanism in which substrates and active-site residues reposition to allow the peptidol transferase reaction. Expand
The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide,Expand
DNA Polymerases: Structural Diversity and Common Mechanisms*
  • T. Steitz
  • Chemistry, Medicine
  • The Journal of Biological Chemistry
  • 18 June 1999
Of particular interest are the role of editing in the fidelity of copying, the common enzymatic mechanism of polymerases, and the manners in which different domain structures function in the polymerase reaction in analogous ways. Expand