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The complete atomic structure of the large ribosomal subunit at 2.4 A resolution.
The large ribosomal subunit catalyzes peptide bond formation and binds initiation, termination, and elongation factors. We have determined the crystal structure of the large ribosomal subunit fromExpand
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The structural basis of ribosome activity in peptide bond synthesis.
Using the atomic structures of the large ribosomal subunit from Haloarcula marismortui and its complexes with two substrate analogs, we establish that the ribosome is a ribozyme and address theExpand
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Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitor.
A 3.5 angstrom resolution electron density map of the HIV-1 reverse transcriptase heterodimer complexed with nevirapine, a drug with potential for treatment of AIDS, reveals an asymmetric dimer. TheExpand
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The kink‐turn: a new RNA secondary structure motif
Analysis of the Haloarcula marismortui large ribosomal subunit has revealed a common RNA structure that we call the kink‐turn, or K‐turn. The six K‐turns in H.marismortui 23S rRNA superimpose with anExpand
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Identifying nonpolar transbilayer helices in amino acid sequences of membrane proteins.
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The structure of the E. coli recA protein monomer and polymer
The crystal structure of the recA protein from Escherichia coli at 2.3-Å resolution reveals a major domain that binds ADP and probably single- and double-stranded DNA. Two smaller subdomains at the NExpand
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The roles of ribosomal proteins in the structure assembly, and evolution of the large ribosomal subunit.
The structures of ribosomal proteins and their interactions with RNA have been examined in the refined crystal structure of the Haloarcula marismortui large ribosomal subunit. The protein structuresExpand
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Structure of the replicating complex of a pol alpha family DNA polymerase.
We describe the 2.6 A resolution crystal structure of RB69 DNA polymerase with primer-template DNA and dTTP, capturing the step just before primer extension. This ternary complex structure in theExpand
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Crystal structure of a CAP-DNA complex: the DNA is bent by 90 degrees
The 3 angstrom resolution crystal structure of the Escherichia coli catabolite gene activator protein (CAP) complexed with a 30-base pair DNA sequence shows that the DNA is bent by 90 degrees. ThisExpand
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The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Crystal structures of the Haloarcula marismortui large ribosomal subunit complexed with the 16-membered macrolide antibiotics carbomycin A, spiramycin, and tylosin and a 15-membered macrolide,Expand
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