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Spectroscopic and voltammetric studies on copper complexes of 2,9-dimethyl-1,10-phenanthrolines bound to calf thymus DNA
Mixed ligand ruthenium(II) complexes of bis(pyrid-2-yl)-/bis(benzimidazol-2-yl)-dithioether and diimines: study of non-covalent DNA binding and cytotoxicity.
- V. Rajendiran, M. Murali, E. Suresh, Sarika Sinha, K. Somasundaram, M. Palaniandavar
- ChemistryDalton transactions
- 7 January 2008
The cytotoxicities of the dppz complexes 3 and 6, which avidly bind to DNA, have been examined by screening them against cell lines of different cancer origins, and it is noteworthy that 6 exhibits selectivity with higher cytotoxicity against the melanoma cancer cell line (A375) than other cell lines.
Interaction of rac-[M(diimine)3]2+ (M=Co, Ni) complexes with CT DNA: role of 5,6-dmp ligand on DNA binding and cleavage and cytotoxicity.
- S. Ramakrishnan, E. Suresh, A. Riyasdeen, M. A. Akbarsha, M. Palaniandavar
- Chemistry, BiologyDalton transactions
- 18 March 2011
The CV and DPV responses indicate that the DNA-bound dpq complexes are stabilized in the lower oxidation state of Co(II) more than in the Co(III) oxidation state.
Spectral, viscometric and electrochemical studies on mixed ligand cobalt(III) complexes of certain diimine ligands bound to calf thymus DNA
Mixed-ligand copper(II)-phenolate complexes: effect of coligand on enhanced DNA and protein binding, DNA cleavage, and anticancer activity.
The observed IC50 values reveal that complex 4, which effects conformational change on DNA and binds to BSA more strongly, exhibits a cytotoxicity higher than the other complexes, suggesting that 4 can be explored further as a potential anticancer drug.
Induction of cell death by ternary copper(II) complexes of L-tyrosine and diimines: role of coligands on DNA binding and cleavage and anticancer activity.
Interestingly, complex 4 interacts with DNA more strongly than all of the other complexes through partial intercalation of the extended planar ring of dpq with DNA base stack, which suggests the involvement of 5,6-dimethyl groups on the phen ring in hydrophobic interaction with DNA surface.
Ternary dinuclear copper(II) complexes of a hydroxybenzamide ligand with diimine coligands: the 5,6-dmp ligand enhances DNA binding and cleavage and induces apoptosis.
- S. Ramakrishnan, Dhanasekaran Shakthipriya, E. Suresh, V. S. Periasamy, M. A. Akbarsha, M. Palaniandavar
- Chemistry, BiologyInorganic chemistry
- 14 June 2011
The dinuclear copper(II) complexes have been found to induce nuclear condensation and fragmentation in cell lines, and it triggers activation of caspases by releasing cytochrome c from mitochondria to cytosol, suggesting that it induces apoptosis in cells via the mitochondrial pathway.
Structures, spectra, and DNA-binding properties of mixed ligand copper(II) complexes of iminodiacetic acid: the novel role of diimine co-ligands on DNA conformation and hydrolytic and oxidative…
Copper(II) complexes of 1,10-phenanthroline-derived ligands: studies on DNA binding properties and nuclease activity.