T. Brown

Publications493
h-index58
Citations13,373
Highly Influential Citations241
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Detection of PCR products using self-probing amplicons and fluorescence
TLDR
This work describes a new technology that is simple to use, gives highly specific information, and avoids the major difficulties of the alternative methods of molecular diagnostics.
Crystal Structure of a G:T/U Mismatch-Specific DNA Glycosylase Mismatch Recognition by Complementary-Strand Interactions
Crystal structure of a thwarted mismatch glycosylase DNA repair complex
TLDR
The crystal structure of the Escherichia coli MUG enzyme complexed with an oligonucleotide containing a non‐hydrolysable deoxyuridine analogue mismatched with guanine is determined, providing the first structure of an intact substrate‐nucleotide productively bound to a hydrolytic DNA glycosylase.
Genomic sequence correction by single‐stranded DNA oligonucleotides: role of DNA synthesis and chemical modifications of the oligonucleotide ends
Single‐stranded oligonucleotides (ssODN) can induce site‐specific genetic alterations in selected mammalian cells, but the involved mechanisms are not known.
Nucleic acid base analog FRET-pair facilitating detailed structural measurements in nucleic acid containing systems.
TLDR
The first nucleobase analog fluorescence resonance energy transfer (FRET)-pair is presented and possibly the first truly solid experimental support to the dependence of energy transfer efficiency on orientation of involved transition dipoles as predicted by the Forster theory is given.
Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes.
TLDR
This work has used thermal melting, circular dichroism, and gel electrophoresis to examine the topology and stability of intramolecular G-quadruplexes that are formed by sequences of the type d(GnT)4 and d(T2)4 (n = 3-7) in the presence of varying concentrations of sodium and potassium.
Crystal structure of an octameric RuvA-Holliday junction complex.
Comparison of the electrophoretic and hydrodynamic properties of DNA and RNA oligonucleotide duplexes.
Comparison of the thermodynamic stabilities and solution conformations of DNA.RNA hybrids containing purine-rich and pyrimidine-rich strands with DNA and RNA duplexes.
TLDR
The conformations and thermodynamic stabilities of duplexes containing purine-rich and pyrimidine-rich DNA and RNA strands have been measured by UV melting, electrophoresis, circular dichroism, and NMR spectroscopy and showed conformational properties intermediate between those of DNA.
Affinity of mismatch-binding protein MutS for heteroduplexes containing different mismatches.
We have used bandshift analysis to measure the interaction between the Escherichia coli mismatch-binding protein MutS and synthetic DNA fragments containing all possible DNA mismatches as well as an…
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