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MTHFD1 gene

Known as: MTHFD1, METHYLENETETRAHYDROFOLATE DEHYDROGENASE/METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE/FORMYLTETRAHYDROFOLATE SYNTHETASE, NADP(+)-DEPENDENT, methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 
This gene plays a role in folate metabolism.
National Institutes of Health

Related topics

Related topics

8 relations
Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, MitochondrialC-1-Tetrahydrofolate Synthase, CytoplasmicHydrolysisMTHFD1L gene

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formyl-methenyl-methylenetetrahydrofolate synthetase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels
Background The polymorphism of methylenetetrahydrofolate dehydrogenase (MTHFD1) has been reported as a risk factor for neural… 
2013
2013
Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.
Impaired utilization of folate is caused by insufficient dietary intake and/or genetic variation and has been shown to prompt… 
2011
2011
Head and neck carcinogenesis : impact of MTHFD 1 G 1958 A polymorphism
Objective: To investigate the MTHFD1 G1958A polymorphism involved in the folate metabolism as a risk for head and neck cancer… 
2009
2009
Association between HIC1 and RASSF1A promoter hypermethylation with MTHFD1 G1958A polymorphism and clinicopathological features of breast cancer in Iranian patients.
BACKGROUND Ras-associated domain family 1 (RASSF1A) and hypermethylated in cancer (HIC1) genes are methylated more frequently in… 
2009
2009
Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer
Carcinogenesis may result from abnormal methylation of cancer-related genes regulatory sequence. Though, the polymorphic variants… 
2007
2007
The methylenetetrahydrofolate dehydrogenase (MTHFD1) 1958G>A variant is not associated with spina bifida risk in the Dutch population
To the Editor: The tri-functional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase… 
Highly Cited
2005
Highly Cited
2005
A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss.
Low maternal folate or vitamin B12 status has been implicated in numerous pregnancy complications including spontaneous abortion… 
Highly Cited
2005
Highly Cited
2005
MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae
This study examined the relationship between folate/homocysteine‐related genetic polymorphisms: MTHFD1 1958G → A (R653Q), MTHFR… 
2005
2005
Folate‐related genes and omphalocele
Women who take folic acid in the periconceptional period greatly reduce their chances of having a child with a neural tube defect… 
1980
1980
Enzymic preparations of radiolabeled +-L-5-methyltetrahydrofolate and +-L-formyltetrahydrofolate.
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