Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer

@article{Kruszyna2009PolymorphicVO,
  title={Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer},
  author={Łukasz Kruszyna and Margarita Lianeri and Małgorzata Rydzanicz and Marzena Gajęcka and Krzysztof Szyfter and Paweł P Jagodziński},
  journal={Molecular Biology Reports},
  year={2009},
  volume={37},
  pages={241-247}
}
Carcinogenesis may result from abnormal methylation of cancer-related genes regulatory sequence. Though, the polymorphic variants of genes encoding enzymes of folate and methionine metabolism may have an effect on DNA methylation. Using PCR-RFLPs, we examined the polymorphism distribution of genes encoding methionine synthase (MTR); 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase (MTHFD1); and… CONTINUE READING

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DNA promoter methylation in breast tumors: no association with genetic polymorphisms in MTHFR and MTR.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology • 2009
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