Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer

  title={Polymorphic variants of folate metabolism genes and the risk of laryngeal cancer},
  author={Łukasz Kruszyna and Margarita Lianeri and Małgorzata Rydzanicz and Marzena Gajęcka and Krzysztof Szyfter and Paweł P Jagodziński},
  journal={Molecular Biology Reports},
Carcinogenesis may result from abnormal methylation of cancer-related genes regulatory sequence. Though, the polymorphic variants of genes encoding enzymes of folate and methionine metabolism may have an effect on DNA methylation. Using PCR-RFLPs, we examined the polymorphism distribution of genes encoding methionine synthase (MTR); 5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methenyltetrahydrofolate cyclohydrolase and 10-formyltetrahydrofolate synthetase (MTHFD1); and… CONTINUE READING


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