M. den Heijer
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Hundreds of variants clustered in genomic loci and biological pathways affect human height
Most common human traits and diseases have a polygenic pattern of inheritance: DNA sequence variants at many genetic loci influence the phenotype. Genome-wide association (GWA) studies have… Expand
Association analyses of 249,796 individuals reveal eighteen new loci associated with body mass index
Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between… Expand
Psoriasis is associated with increased beta-defensin genomic copy number.
Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch… Expand
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a… Expand
Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.
- H. Stanescu, M. Arcos‐Burgos, +26 authors R. Kleta
- The New England journal of medicine
- 16 February 2011
BACKGROUND Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven… Expand
Homocysteine, MTHFR and risk of venous thrombosis: a meta‐analysis of published epidemiological studies
- M. den Heijer, S. Lewington, R. Clarke
- Journal of thrombosis and haemostasis : JTH
- 1 February 2005
Summary. Context: It has been suggested that elevated total plasma homocysteine levels are associated with the risk of venous thrombosis. Objective: To assess the relationship of homocysteine and… Expand
Age- and gender-specific reference values of estimated GFR in Caucasians: the Nijmegen Biomedical Study.
- J. Wetzels, L. Kiemeney, D. Swinkels, H. Willems, M. den Heijer
- Kidney international
- 1 September 2007
The Nijmegen Biomedical Study is a population-based cross-sectional study conducted in the eastern part of the Netherlands. As part of the overall study, we provide reference values of estimated… Expand
Accurate, high-throughput typing of copy number variation using paralogue ratios from dispersed repeats
- J. A. Armour, R. Palla, P. Zeeuwen, M. den Heijer, J. Schalkwijk, E. Hollox
- Medicine, Biology
- Nucleic acids research
- 14 December 2006
Recent work has demonstrated an unexpected prevalence of copy number variation in the human genome, and has highlighted the part this variation may play in predisposition to common phenotypes. Some… Expand
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide… Expand
Thyroid function and prevalence of anti-thyroperoxidase antibodies in a population with borderline sufficient iodine intake: influences of age and sex.
BACKGROUND We present a large European population-based study of thyroid function, performed in a population with longstanding borderline sufficient iodine intake. METHODS The Nijmegen Biomedical… Expand