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C-1-Tetrahydrofolate Synthase, Cytoplasmic

Known as: MTHFD1, C1-THF Synthase, 5,10-Methylenetetrahydrofolate Dehydrogenase, 5,10-Methylenetetrahydrofolate Cyclohydrolase, 10-Formyltetrahydrofolate Synthetase 
C-1-tetrahydrofolate synthase, cytoplasmic (935 aa, ~102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism… Expand
National Institutes of Health

Papers overview

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2017
2017
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was… Expand
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2016
2016
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with… Expand
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Review
2013
Review
2013
Methotrexate (MTX) is the central drug in the management of rheumatoid arthritis (RA) and other immune mediated inflammatory… Expand
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2012
2012
Abstract The prediction of high-dose methotrexate (HD-MTX) toxicity is a key issue in the individualization of treatment in… Expand
Highly Cited
2009
Highly Cited
2009
Mitochondrial folate-dependent one-carbon (1-C) metabolism converts 1-C donors such as serine and glycine to formate, which is… Expand
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Highly Cited
2007
Highly Cited
2007
The interconversion of folates by the one-carbon metabolism pathway is essential for the synthesis of precursors used in DNA… Expand
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2005
2005
There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even… Expand
1993
1993
The protein product of the ADE3 gene of the yeast Saccharomyces cerevisiae has been identified as the cytoplasmic trifunctional… Expand
Highly Cited
1986
Highly Cited
1986
The sequence of a cloned copy of the yeast ADE3 gene, which encodes the trifunctional enzyme C1-5,6,7,8-tetrahydrofolate (THF… Expand