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C-1-Tetrahydrofolate Synthase, Cytoplasmic

Known as: MTHFD1, C1-THF Synthase, 5,10-Methylenetetrahydrofolate Dehydrogenase, 5,10-Methylenetetrahydrofolate Cyclohydrolase, 10-Formyltetrahydrofolate Synthetase 
C-1-tetrahydrofolate synthase, cytoplasmic (935 aa, ~102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism… 
National Institutes of Health

Related topics

Related topics

9 relations
CytoplasmEnzyme GeneHydrolysisLigase Gene

Broader (1)

formyl-methenyl-methylenetetrahydrofolate synthetase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Association of Endothelial Nitric Oxide Synthase and MTHFD1 Polymorphisms with Idiopathic Recurrent Pregnancy Loss in Iranian Women
2016
2016
Function of yeast cytoplasmic Cl-tetrahydrofolate synthase (Saccharomyces cerevisiae/heterologous gene expression/ADE3/purine biosynthesis)
The protein product of the ADE3 gene of the yeast Saccharomyces cerevisiae has been identified as the cy- toplasmic trifunctional… 
Highly Cited
2012
Highly Cited
2012
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
Abstract The prediction of high-dose methotrexate (HD-MTX) toxicity is a key issue in the individualization of treatment in… 
2008
2008
Lack of association of polymorphisms in homocysteine metabolism genes with pseudoexfoliation syndrome and glaucoma
Purpose To evaluate genes involved in homocysteine metabolism as secondary risk factors for pseudoexfoliation syndrome (PXFS) and… 
2004
2004
Effect of Polymorphisms in Folate Related Genes on Side Effects of High Dose MTX Treatment in Childhood Acute Lymphoblastic Leukemia.
Introduction. High dose (2 – 3 g/m2) methotrexate (MTX, an anti-folate) is used in the treatment of pediatric acute lymphoblastic… 
2003
2003
Human Mitochondrial C 1-Tetrahydrofolate Synthase GENE STRUCTURE , TISSUE DISTRIBUTION OF THE MRNA , AND IMMUNOLOCALIZATION IN CHINESE HAMSTER OVARY CELLS
C1-tetrahydrofolate (THF) synthase is a trifunctional enzyme found in eukaryotes that contains the activities 10-formyl-THF… 
Highly Cited
1986
Highly Cited
1986
Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.
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