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C-1-Tetrahydrofolate Synthase, Cytoplasmic

Known as: MTHFD1, C1-THF Synthase, 5,10-Methylenetetrahydrofolate Dehydrogenase, 5,10-Methylenetetrahydrofolate Cyclohydrolase, 10-Formyltetrahydrofolate Synthetase 
C-1-tetrahydrofolate synthase, cytoplasmic (935 aa, ~102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism… Expand
National Institutes of Health

Related topics

Related topics

9 relations
CytoplasmEnzyme GeneHydrolysisLigase Gene
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Broader (1)

formyl-methenyl-methylenetetrahydrofolate synthetase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was… Expand
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2016
2016
MTHFD1 controls DNA methylation in Arabidopsis
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with… Expand
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2016
2016
Association of Endothelial Nitric Oxide Synthase and MTHFD1 Polymorphisms with Idiopathic Recurrent Pregnancy Loss in Iranian Women
 
Review
2013
Review
2013
Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?
Methotrexate (MTX) is the central drug in the management of rheumatoid arthritis (RA) and other immune mediated inflammatory… Expand
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2012
2012
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
Abstract The prediction of high-dose methotrexate (HD-MTX) toxicity is a key issue in the individualization of treatment in… Expand
Highly Cited
2009
Highly Cited
2009
Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*
Mitochondrial folate-dependent one-carbon (1-C) metabolism converts 1-C donors such as serine and glycine to formate, which is… Expand
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Highly Cited
2007
Highly Cited
2007
Association of Polymorphisms in One-Carbon Metabolism Genes and Postmenopausal Breast Cancer Incidence
The interconversion of folates by the one-carbon metabolism pathway is essential for the synthesis of precursors used in DNA… Expand
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2005
2005
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
There is growing evidence that folate metabolism is involved in migraine pathophysiology, mainly in migraine with aura. Even… Expand
1993
1993
Function of yeast cytoplasmic C1-tetrahydrofolate synthase.
The protein product of the ADE3 gene of the yeast Saccharomyces cerevisiae has been identified as the cytoplasmic trifunctional… Expand
Highly Cited
1986
Highly Cited
1986
Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.
The sequence of a cloned copy of the yeast ADE3 gene, which encodes the trifunctional enzyme C1-5,6,7,8-tetrahydrofolate (THF… Expand
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