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C-1-Tetrahydrofolate Synthase, Cytoplasmic
Known as:
MTHFD1
, C1-THF Synthase
, 5,10-Methylenetetrahydrofolate Dehydrogenase, 5,10-Methylenetetrahydrofolate Cyclohydrolase, 10-Formyltetrahydrofolate Synthetase
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C-1-tetrahydrofolate synthase, cytoplasmic (935 aa, ~102 kDa) is encoded by the human MTHFD1 gene. This protein plays a role in folic acid metabolism…
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National Institutes of Health
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Related topics
Related topics
9 relations
Cytoplasm
Enzyme Gene
Hydrolysis
Ligase Gene
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Broader (1)
formyl-methenyl-methylenetetrahydrofolate synthetase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
The natural product carolacton inhibits folate-dependent C1 metabolism by targeting FolD/MTHFD
Chengzhang Fu
,
A. Sikandar
,
+6 authors
R. Müller
Nature Communications
2017
Corpus ID: 29475745
The natural product carolacton is a macrolide keto-carboxylic acid produced by the myxobacterium Sorangium cellulosum, and was…
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2016
2016
MTHFD1 controls DNA methylation in Arabidopsis
M. Groth
,
Guillaume Moissiard
,
+14 authors
S. Jacobsen
Nature communications
2016
Corpus ID: 6927735
DNA methylation is an epigenetic mechanism that has important functions in transcriptional silencing and is associated with…
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2016
2016
Association of Endothelial Nitric Oxide Synthase and MTHFD1 Polymorphisms with Idiopathic Recurrent Pregnancy Loss in Iranian Women
Samira Negahdari
,
M. Dehghani
,
J. Asl
,
A. Bidmeshkipour
2016
Corpus ID: 79745220
Review
2013
Review
2013
Old drugs, old problems: where do we stand in prediction of rheumatoid arthritis responsiveness to methotrexate and other synthetic DMARDs?
V. Romão
,
H. Canhão
,
J. Fonseca
BMC Medicine
2013
Corpus ID: 1734846
Methotrexate (MTX) is the central drug in the management of rheumatoid arthritis (RA) and other immune mediated inflammatory…
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Highly Cited
2012
Highly Cited
2012
Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
N. Erčulj
,
B. Kotnik
,
M. Debeljak
,
J. Jazbec
,
V. Dolžan
Leukemia & lymphoma
2012
Corpus ID: 40566995
Abstract The prediction of high-dose methotrexate (HD-MTX) toxicity is a key issue in the individualization of treatment in…
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Highly Cited
2009
Highly Cited
2009
Mitochondrial C1-Tetrahydrofolate Synthase (MTHFD1L) Supports the Flow of Mitochondrial One-carbon Units into the Methyl Cycle in Embryos*
Schuyler T. Pike
,
Rashmi Rajendra
,
K. Artzt
,
D. Appling
The Journal of Biological Chemistry
2009
Corpus ID: 41422790
Mitochondrial folate-dependent one-carbon (1-C) metabolism converts 1-C donors such as serine and glycine to formate, which is…
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Highly Cited
2007
Highly Cited
2007
Association of Polymorphisms in One-Carbon Metabolism Genes and Postmenopausal Breast Cancer Incidence
V. Stevens
,
M. McCullough
,
+4 authors
E. Calle
Cancer Epidemiology Biomarkers & Prevention
2007
Corpus ID: 25945965
The interconversion of folates by the one-carbon metabolism pathway is essential for the synthesis of precursors used in DNA…
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2005
2005
Thymidylate synthase promoter tandem repeat and MTHFD1 R653Q polymorphisms modulate the risk for migraine conferred by the MTHFR T677 allele.
A. Oterino
,
N. Valle
,
+7 authors
C. Cid
Brain research. Molecular brain research
2005
Corpus ID: 27492864
1993
1993
Function of yeast cytoplasmic C1-tetrahydrofolate synthase.
J. M. Song
,
J. Rabinowitz
Proceedings of the National Academy of Sciences…
1993
Corpus ID: 627700
The protein product of the ADE3 gene of the yeast Saccharomyces cerevisiae has been identified as the cytoplasmic trifunctional…
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Highly Cited
1986
Highly Cited
1986
Nucleotide sequence of the Saccharomyces cerevisiae ADE3 gene encoding C1-tetrahydrofolate synthase.
C. Staben
,
J. Rabinowitz
The Journal of biological chemistry
1986
Corpus ID: 40708591
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