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MTHFD1L gene

Known as: MITOCHONDRIAL C1-TETRAHYDROFOLATE SYNTHASE, Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like Gene, METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1-LIKE, NADP(+)-DEPENDENT 
This gene is involved in the regulation of folate metabolism.
National Institutes of Health

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Narrower (2)

Fumarate Hydratase, Mitochondrial, humanMTHFD1L wt Allele
MTHFD1 geneMonofunctional C1-Tetrahydrofolate Synthase, Mitochondrialfolic acid metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
High expression of folate cycle enzyme MTHFD1L correlates with poor prognosis and increased proliferation and migration in colorectal cancer
Aims: To investigate the expression and clinical significance of methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) in… 
2019
2019
MTHFD1L, A Folate Cycle Enzyme, Is Involved in Progression of Colorectal Cancer
2016
2016
Formate supplementation enhances folate-dependent nucleotide biosynthesis and prevents spina bifida in a mouse model of folic acid-resistant neural tube defects
2014
2014
Genetic Polymorphism rs6922269 in the MTHFD1L Gene Is Associated with Survival and Baseline Active Vitamin B12 Levels in Post-Acute Coronary Syndromes Patients
Background and Aims The methylene-tetrahydrofolate dehydrogenase (NADP+ dependent) 1-like (MTHFD1L) gene is involved in… 
2014
2014
An NTD‐Associated Polymorphism in the 3′ UTR of MTHFD1L can Affect Disease Risk by Altering miRNA Binding
Maternal folate levels and polymorphisms in folate‐related genes are known risk factors for neural tube defects (NTDs). SNPs in… 
Highly Cited
2012
Highly Cited
2012
Deletion of Mthfd1l causes embryonic lethality and neural tube and craniofacial defects in mice
Maternal supplementation with folic acid is known to reduce the incidence of neural tube defects (NTDs) by as much as 70… 
Highly Cited
2011
Highly Cited
2011
Implications of discoveries from genome-wide association studies in current cardiovascular practice.
Genome-wide association studies (GWAS) have identified several genetic variants associated with coronary heart disease (CHD), and… 
Highly Cited
2010
Highly Cited
2010
Dementia Revealed: Novel Chromosome 6 Locus for Late-Onset Alzheimer Disease Provides Genetic Evidence for Folate-Pathway Abnormalities
Genome-wide association studies (GWAS) of late-onset Alzheimer disease (LOAD) have consistently observed strong evidence of… 
Highly Cited
2009
Highly Cited
2009
A common variant in MTHFD1L is associated with neural tube defects and mRNA splicing efficiency
Polymorphisms in folate‐related genes have emerged as important risk factors in a range of diseases including neural tube defects… 
Review
2008
Review
2008
Mitochondrial methylenetetrahydrofolate dehydrogenase, methenyltetrahydrofolate cyclohydrolase, and formyltetrahydrofolate synthetases.
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