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MTHFD1L gene

Known as: MITOCHONDRIAL C1-TETRAHYDROFOLATE SYNTHASE, Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 1-Like Gene, METHYLENETETRAHYDROFOLATE DEHYDROGENASE 1-LIKE, NADP(+)-DEPENDENT 
This gene is involved in the regulation of folate metabolism.
National Institutes of Health

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Fumarate Hydratase, Mitochondrial, humanMTHFD1L wt Allele
MTHFD1 geneMonofunctional C1-Tetrahydrofolate Synthase, Mitochondrialfolic acid metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
MTHFD1L as a folate cycle enzyme correlates with prognostic outcome and its knockdown impairs cell invasive behaviors in osteosarcoma via mediating the AKT/mTOR pathway
Abstract Osteosarcoma (OS) is the most frequent primary malignancy initially in bone with multiple genomic aberrations… 
2018
2018
A Common Variant in MTHFD1L is Associated with Increased Risk for Spina Bifida
Genetic polymorphisms within folate pathway genes represent potentially meaningful risk factors for neural tube defects (NTDs… 
2017
2017
The folate cycle is a new metabolic weakness of cancer
ABSTRACT Cancer cells harness nutrients to support its rapid proliferation through metabolic reprogramming. Our report identified… 
2017
2017
A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder
Bipolar disorder is a common and severe mental illness with unsolved pathophysiology. A genome-wide association study (GWAS) has… 
2015
2015
Glutathione metabolism links FOXRED1 to NADH:ubiquinone oxidoreductase (complex I) deficiency: A hypothesis.
2012
2012
Replication of the MTHFD1L gene association with late-onset Alzheimer's disease in a Northern Han Chinese population.
We conducted a replication study of the 2 genetic variants, rs11754661 and rs2073067, in MTHFD1L that have been recently reported… 
Highly Cited
2011
Highly Cited
2011
Association of SNP rs17465637 on Chromosome 1q41 and rs599839 on 1p13.3 with Myocardial Infarction in an American Caucasian Population
Recent genome‐wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were… 
2011
2011
The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population.
The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome… 
2011
2011
The MTHFD1L gene rs11754661 marker is associated with susceptibility to Alzheimer's disease in the Chinese Han population
2009
2009
Variation in the methylenetetrahydrofolate dehydrogenase 1‐like (MTHFD1L) gene and cardiovascular disease (CVD) risk
Two recent genome‐wide association (GWA) studies identified an intronic SNP (rs6922269) in a region of high linkage… 
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