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folic acid metabolism

Known as: vitamin B9 metabolism, vitamin M metabolic process, vitamin M metabolism 
The chemical reactions and pathways involving folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex… 
National Institutes of Health

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Related topics

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Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, MitochondrialC-1-Tetrahydrofolate Synthase, CytoplasmicFOLH1 geneFOLH1 wt Allele

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folic acid catabolism

Papers overview

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Highly Cited
2008
Highly Cited
2008
Functional Polymorphisms in Folate Metabolism Genes Influence the Risk of Meningioma and Glioma
Folate metabolism plays an important role in carcinogenesis. To test the hypothesis that polymorphic variation in the folate… 
Highly Cited
2007
Highly Cited
2007
One‐carbon metabolism‐related gene polymorphisms and risk of head and neck squamous cell carcinoma: Case–control study
Low consumption of vegetables and fruits, which leads to insufficient folate intake, is associated with increased risk of several… 
Highly Cited
2006
Highly Cited
2006
The Schedule-Dependent Effects of the Novel Antifolate Pralatrexate and Gemcitabine Are Superior to Methotrexate and Cytarabine in Models of Human Non-Hodgkin's Lymphoma
Purpose: Methotrexate is known to synergize with cytarabine [1-β-d-arabinofuranosylcytosine (ara-C)] in a schedule-dependent… 
Highly Cited
2004
Highly Cited
2004
MTHFR C677T and A1298C Polymorphisms
5,10-methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism, diverting metabolites toward methylation… 
Highly Cited
1999
Highly Cited
1999
Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation
Background: The antiepileptic drug valproic acid (VPA) may be teratogenic. The mechanism of teratogenicity remains unclear, but… 
Highly Cited
1982
Highly Cited
1982
Syntheses of alpha- and gamma-substituted amides, peptides, and esters of methotrexate and their evaluation as inhibitors of folate metabolism.
N-[4-[[(Benzyloxy)carbonyl]methylamino]benzoyl]-L-glutamic acid alpha-benzyl ester (2) and gamma-benzyl ester (6) served as key… 
Highly Cited
1981
Highly Cited
1981
Hepatic folate metabolism in the chronic alcoholic monkey.
To assess the role of altered hepatic folate metabolism in the pathogenesis of the folate deficiency of chronic alcoholism, the… 
Highly Cited
1970
Highly Cited
1970
Congenital defects in folate utilization.
Highly Cited
1968
Highly Cited
1968
Deranged DNA Synthesis by Bone Marrow from Vitamin B12‐Deficient Humans *
Summary. The synthesis of thymine DNA from deoxyuridine and uridine was studied by culturing human bone marrow for 1–3 hours in… 
Highly Cited
1968
Highly Cited
1968
Effects of trimethoprim on folate metabolism in man
Recent studies have demonstrated a synergistic effect of dihydrofolate reductase (DHFR) inhibitors and sulfonamides in the… 
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