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FOLH1 gene

Known as: FOLH, GLUTAMATE CARBOXYPEPTIDASE II, folate hydrolase (prostate-specific membrane antigen) 1 
This gene plays a role in folate metabolism. It is also involved in neuronal transmission.
National Institutes of Health

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FOLH1 wt Allele
HydrolysisMolecular TransportNAALADL1 geneSynaptic Transmission

Papers overview

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Highly Cited
2017
Highly Cited
2017
PSMA-Targeted Theranostic Nanocarrier for Prostate Cancer
Herein, we report the use of a theranostic nanocarrier (Folate-HBPE(CT20p)) to deliver a therapeutic peptide to prostate cancer… 
Highly Cited
2011
Highly Cited
2011
Epistatic interactions between loci of one-carbon metabolism modulate susceptibility to breast cancer
In view of growing body of evidence substantiating the role of aberrations in one-carbon metabolism in the pathophysiology of… 
Highly Cited
2008
Highly Cited
2008
Structural basis of interactions between human glutamate carboxypeptidase II and its substrate analogs.
Highly Cited
2007
Highly Cited
2007
Expression of glutamate carboxypeptidase II in human brain
Highly Cited
2004
Highly Cited
2004
Folate, homocysteine, and negative symptoms in schizophrenia.
OBJECTIVE Because glutamate carboxypeptidase II (GCPII) regulates both folate absorption and activation of N-methyl-d-aspartic… 
Highly Cited
2003
Highly Cited
2003
Evaluation of genetic variants in the reduced folate carrier and in glutamate carboxypeptidase II for spina bifida risk.
Highly Cited
2003
Highly Cited
2003
Effects of the glutamate carboxypeptidase II (GCP2 1561C>T) and reduced folate carrier (RFC1 80G>A) allelic variants on folate and total homocysteine levels in kidney transplant patients.
BACKGROUND The effect of the glutamate carboxypeptidase II GCP2 1561C>T and the reduced folate carrier 1 RFC1 80G>A polymorphisms… 
Highly Cited
2002
Highly Cited
2002
Upregulation of prostate specific membrane antigen/folate hydrolase transcription by an enhancer.
2002
2002
The glutamate carboxypeptidase gene II (C>T) polymorphism does not affect folate status in the Framingham Offspring cohort.
Glutamate carboxypeptidase II (GCPII) hydrolyzes polyglutamyl folates before their absorption. Recently, a 1561 C>T polymorphism… 
Highly Cited
1998
Highly Cited
1998
Mapping, genomic organization and promoter analysis of the human prostate-specific membrane antigen gene.
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