Immune responses against PSMA after gene-based vaccination for immunotherapy – A: results from immunizations in animals

Abstract

Two plasmid DNA vaccines, encoding either products that are retained in the cytosol and degraded in the proteasome (tVacs; hPSMAt), or secreted proteins (sVacs; hPSMAs) were evaluated for stimulation of cytotoxic cell or antibody responses. Immunization with both vectors led to generation of cell cytotoxicity providing granulocyte-macrophage colony… (More)
DOI: 10.1038/sj.cgt.7700914

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