• Publications
  • Influence
Translocator protein (18kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function.
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is located mainly in the outer mitochondrial membrane. The PBR binds toExpand
  • 1,104
  • 70
Manganese: recent advances in understanding its transport and neurotoxicity.
The present review is based on presentations from the meeting of the Society of Toxicology in San Diego, CA (March 2006). It addresses recent developments in the understanding of the transport ofExpand
  • 476
  • 26
  • PDF
Manganese and Parkinson’s Disease: A Critical Review and New Findings
  • T. Guilarte
  • Medicine
  • Environmental health perspectives
  • 19 April 2010
Background Excess accumulation of manganese (Mn) in the brain results in a neurological syndrome with cognitive, psychiatric, and movement abnormalities. The highest concentrations of Mn in the brainExpand
  • 269
  • 19
  • PDF
Lead neurotoxicity: From exposure to molecular effects
The effects of lead (Pb(2+)) on human health have been recognized since antiquity. However, it was not until the 1970s that seminal epidemiological studies provided evidence on the effects of Pb(2+)Expand
  • 307
  • 18
Nigrostriatal dopamine system dysfunction and subtle motor deficits in manganese-exposed non-human primates
We tested the hypothesis that movement abnormalities induced by chronic manganese (Mn) exposure are mediated by dysfunction of the nigrostriatal dopamine system in the non-human primate striatum.Expand
  • 161
  • 10
In vivo modulation of the Parkinsonian phenotype by Nrf2.
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD) and in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of PD. In this report we show that Nrf2, aExpand
  • 170
  • 9
Environmental lead exposure during early life alters granule cell neurogenesis and morphology in the hippocampus of young adult rats
Exposure to environmentally relevant levels of lead (Pb(2+)) during early life produces deficits in hippocampal synaptic plasticity in the form of long-term potentiation (LTP) and spatial learning inExpand
  • 120
  • 9
Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure
Long‐term deficits in cognitive function are the principal effects of lead (Pb2+) exposure in children and can be modeled in experimental animals. Current therapeutic approaches in the treatment ofExpand
  • 190
  • 8
Impairment of nigrostriatal dopamine neurotransmission by manganese is mediated by pre‐synaptic mechanism(s): implications to manganese‐induced parkinsonism
The long‐term consequences of chronic manganese (Mn) exposure on neurological health is a topic of great concern to occupationally‐exposed workers and in populations exposed to moderate levels of Mn.Expand
  • 130
  • 8
Peripheral benzodiazepine receptor imaging in CNS demyelination: functional implications of anatomical and cellular localization.
The peripheral benzodiazepine receptor (PBR) has been used as a sensitive marker to visualize and measure glial cell activation associated with various forms of brain injury and inflammation.Expand
  • 127
  • 8
  • PDF