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Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
Dementia developed in 111 subjects, including 83 given a diagnosis of Alzheimer's disease, over a median follow-up period of eight years, and plasma levels of folate and vitamins B12 and B6 increased. Expand
Homocysteine metabolism.
  • J. Selhub
  • Medicine
  • Annual review of nutrition
  • 1999
The studies with animal models indicated the possibility that the effect of elevated homocysteine is multifactorial, affecting both the vascular wall structure and the blood coagulation system. Expand
Vitamin status and intake as primary determinants of homocysteinemia in an elderly population.
A strong association between homocysteine concentration and folate, vitamin B12, and vitamin B6 status, as well as age is indicated, suggesting that a substantial majority of the cases of high homocy steine in this older population can be attributed to vitamin status. Expand
Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.
Support is provided for an important role of folate metabolism in colon carcinogenesis and suggests that the 677C-->IT mutation in MTHFR reduces colon cancer risk, perhaps by increasing 5,10-methylenetetrahydrofolate levels for DNA synthesis, but that low folate intake or high alcohol consumption may negate some of the protective effect. Expand
The effect of folic acid fortification on plasma folate and total homocysteine concentrations.
The fortification of enriched grain products with folic acid was associated with a substantial improvement in folate status in a population of middle-aged and older adults. Expand
Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort.
This study confirmed the importance of the known determinants of fasting total homocysteine (tHcy) and suggested that other dietary and lifestyle factors, including vitamin B-6, riboflavin, alcohol, and caffeine intakes as well as smoking and hypertension, influence circulating tHcy concentrations. Expand
A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status
The results indicate that the MTHFR C677T polymorphism influences DNA methylation status through an interaction with folate status, and is known to be solely represented in those individuals. Expand
Multiple biomarkers for the prediction of first major cardiovascular events and death.
The use of the 10 contemporary biomarkers that were studied adds only moderately to standard risk factors and only small increases in the ability to classify risk, as measured by the C statistic. Expand
Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification.
In seniors with low vitamin B-12 status, high serum folate was associated with anemia and cognitive impairment when vitamin B -12 status was normal; when it was normal, however, high Serum folatewas associated with protection against cognitive impairment. Expand
Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations.
Individuals with thermolabile MTHFR may have a higher folate requirement for regulation of plasma homocysteine concentrations; folate supplementation may be necessary to prevent fasting hyperhomocysteinemia in such persons. Expand