Fumarate Hydratase, Mitochondrial, human

Known as: FH, Fumarate Hydratase, Mitochondrial, EC 4.2.1.2 
Fumarate hydratase, mitochondrial (510 aa, ~55 kDa) is encoded by the human FH gene. This protein plays a role in the meditation of the citric acid… (More)
National Institutes of Health

Related topics

Related topics

11 relations
Cell RespirationCitrate Cycle (TCA Cycle) PathwayCitric Acid CycleEnzyme Gene
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Broader (1)

MTHFD1L gene

Papers overview

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Highly Cited
2010
Highly Cited
2010
Fumarase: A Mitochondrial Metabolic Enzyme and a Cytosolic/Nuclear Component of the DNA Damage Response
In eukaryotes, fumarase (FH in human) is a well-known tricarboxylic-acid-cycle enzyme in the mitochondrial matrix. However… (More)
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2010
2010
Rational design of HIV-1 fluorescent hydrolysis probes considering phylogenetic variation and probe performance.
Quantitative PCR (qPCR) using fluorescent hydrolysis probes (FH-probes; TaqMan-probes) of variable genomes, such as HIV-1, can… (More)
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2009
2009
CspA-mediated binding of human factor H inhibits complement deposition and confers serum resistance in Borrelia burgdorferi.
Borrelia burgdorferi has developed efficient mechanisms for evading the innate immune response during mammalian infection and has… (More)
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Highly Cited
2007
Highly Cited
2007
The FH mutation database: an online database of fumarate hydratase mutations involved in the MCUL (HLRCC) tumor syndrome and congenital fumarase deficiency
Fumarate hydratase (HGNC approved gene symbol – FH), also known as fumarase, is an enzyme of the tricarboxylic acid (TCA) cycle… (More)
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Highly Cited
2003
Highly Cited
2003
Genetic and functional analyses of FH mutations in multiple cutaneous and uterine leiomyomatosis, hereditary leiomyomatosis and renal cancer, and fumarate hydratase deficiency.
Germline mutations of the fumarate hydratase (FH, fumarase) gene are found in the recessive FH deficiency syndrome and in… (More)
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2000
2000
Characterization of the arabidopsis formin-like protein AFH1 and its interacting protein.
A partial cDNA encoding an Arabidopsis thaliana FH (Formin Homology) protein (AFH1) was used as a probe to clone a full length… (More)
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Highly Cited
1998
Highly Cited
1998
cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis.
A maternally expressed Caenorhabditis elegans gene called cyk-1 is required for polar body extrusion during meiosis and for a… (More)
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Highly Cited
1996
Highly Cited
1996
Two core promotor mutations identified in a hepatitis B virus strain associated with fulminant hepatitis result in enhanced viral replication.
Viral mutations have been implicated in alteration of the biological phenotype of hepatitis B virus (HBV). We recently cloned and… (More)
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1995
1995
The proline-rich P65 protein of Mycoplasma pneumoniae is a component of the Triton X-100-insoluble fraction and exhibits size polymorphism in the strains M129 and FH.
Previously, we described the identification of a novel Mycoplasma pneumoniae M129 protein, named P65 because of its apparent… (More)
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Highly Cited
1983
Highly Cited
1983
Decreased pyruvate dehydrogenase complex activity in Huntington and Alzheimer brain.
The activity of the pyruvate dehydrogenase complex (PDHC) was reduced in affected areas of brain from patients with Huntington… (More)
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