Monofunctional C1-Tetrahydrofolate Synthase, Mitochondrial

Known as: EC 6.3.4.3, Formyltetrahydrofolate Synthetase 
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (978 aa, ~106 kDa) is encoded by the human MTHFD1L gene. This protein is involved in the… Expand
National Institutes of Health

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Enzyme GeneFormate-Tetrahydrofolate LigaseFumarate Hydratase, Mitochondrial, humanHomo sapiens
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2016
2016
Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.
BACKGROUND Moderately high folic acid intake in pregnant women has led to concerns about deleterious effects on the mother and… Expand
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2015
2015
Hydrogenotrophic culture enrichment reveals rumen Lachnospiraceae and Ruminococcaceae acetogens and hydrogen-responsive Bacteroidetes from pasture-fed cattle.
Molecular information suggests that there is a broad diversity of acetogens in the rumen, distinct from any currently isolated… Expand
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2014
2014
Investigation of a new acetogen isolated from an enrichment of the tammar wallaby forestomach
BackgroundForestomach fermentation in Australian marsupials such as wallabies and kangaroos, though analogous to rumen… Expand
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2012
2012
Methanogen Colonisation Does Not Significantly Alter Acetogen Diversity in Lambs Isolated 17 h After Birth and Raised Aseptically
Reductive acetogenesis is not competitive with methanogenesis in adult ruminants, whereas acetogenic bacteria are the dominant… Expand
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2011
2011
The role of homoacetogenic bacteria as efficient hydrogen scavengers in microbial electrochemical cells (MXCs).
We evaluated the consumption of hydrogen gas at the anode of a microbial electrolysis cell (MEC) and characterized the… Expand
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1993
1993
Function of yeast cytoplasmic C1-tetrahydrofolate synthase.
The protein product of the ADE3 gene of the yeast Saccharomyces cerevisiae has been identified as the cytoplasmic trifunctional… Expand
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1991
1991
A pseudogene on the X chromosome for the human trifunctional enzyme MTHFD (methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase).
The human trifunctional folate-dependent protein MTHFD has been mapped to chromosome 14q24 and to the X chromosome was identified… Expand
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1984
1984
The effect of nordihydroguaiaretic acid and related lignans on formyltetrahydrofolate synthetase and carboxylesterase.
The lignans nordihydroguaiaretic acid (NDGA), heminordihydroguaiaretic acid (HNDGA) and norisoguaiacin were found to inhibit… Expand
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1980
1980
Formyl-methenyl-methylenetetrahydrofolate synthetase (combined): a multifunctional protein in eukaryotic folate metabolism.
Publisher Summary This chapter discusses the role of formyl-methenyl methylenetetrahydrofolate synthetase protein in eukaryotic… Expand
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1972
1972
Formyltetrahydrofolate synthetase. Binding of folate substrates and kinetics of the reverse reaction.
Abstract During the fermentation of purines by Clostridium acidi-urici and Clostridium cylindrosporum, formyltetrahydrofolate… Expand
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