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MRE11A wt Allele

Known as: ATLD, HNGS1, Meiotic Recombination 11, S. cerevisiae, Homolog of, A Gene 
Human MRE11A wild-type allele is located in the vicinity of 11q21 and is approximately 77 kb in length. This allele, which encodes double-strand… 
National Institutes of Health

Related topics

Related topics

8 relations
ATM Signaling PathwayDNA RepairElongation by TelomeraseMRE11B gene

Broader (1)

MRE11A gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
γH2AX foci on apparently intact mitotic chromosomes: Not signatures of misrejoining events but signals of unresolved DNA damage
The presence of γH2AX foci on apparently intact mitotic chromosomes is controversial because they challenge the assumed… 
Highly Cited
2012
Highly Cited
2012
The Mre11 Nuclease Is Critical for the Sensitivity of Cells to Chk1 Inhibition
The Chk1 kinase is required for the arrest of cell cycle progression when DNA is damaged, and for stabilizing stalled replication… 
2010
2010
Export of Adenoviral Late mRNA from the Nucleus Requires the Nxf1/Tap Export Receptor
ABSTRACT One important function of the human adenovirus E1B 55-kDa protein is induction of selective nuclear export of viral late… 
2008
2008
Thymidine Selectively Enhances Growth Suppressive Effects of Camptothecin/Irinotecan in MSI+ Cells and Tumors Containing a Mutation of MRE11
Purpose: DNA synthesis inhibitors and damaging agents are widely used in cancer therapy; however, sensitivity of tumors to such… 
Review
2007
Review
2007
DNA damage-induced signalling in ataxia-telangiectasia and related syndromes.
2007
2007
The Mre11/Rad50/Nbs1 Complex Plays an Important Role in the Prevention of DNA Rereplication in Mammalian Cells*
The Mre11/Nbs1/Rad50 complex (MRN) plays multiple roles in the maintenance of genome stability, including repair of double… 
Highly Cited
2006
Highly Cited
2006
The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity
The chemotherapeutic agent temozolomide produces O6-methylguanine (O6MG) in DNA, which triggers futile DNA mismatch repair, DNA… 
Highly Cited
2003
Highly Cited
2003
Inactivation of Cdc13p TriggersMEC1-dependent Apoptotic Signals in Yeast*
Inactivation of the budding yeast telomere binding protein Cdc13 results in abnormal telomeres (exposed long G-strands) and… 
Review
2002
Review
2002
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11
The accumulation of DNA repair proteins at the sites of DNA damage can be visualized in mutagenized cells at the single cell… 
Highly Cited
2001
Highly Cited
2001
Alterations of the double-strand break repair gene MRE11 in cancer.
MRE11 plays a role in DNA double-strand break repair. Hypomorphic mutations of MRE11 have been demonstrated in ataxia… 
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