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A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia was identified by positional cloning on chromosome 11q22-23 and encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control.
Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
- M. Lavin
- Biology, MedicineNature reviews. Molecular cell biology
- 1 October 2008
First described over 80 years ago, ataxia-telangiectasia (A-T) is a paradigm for cancer predisposition and neurodegenerative disorders and has a central role in the understanding of the DNA-damage response, signal transduction and cell-cycle control.
ATM Activation by Oxidative Stress
It is shown that oxidation of ATM directly induces ATM activation in the absence of DNA DSBs and the MRN complex, and that ATM is an important sensor of reactive oxygen species in human cells.
The complexity of p53 stabilization and activation
The post-translational modifications to p53 in response to different stresses and the consequences of these changes are discussed.
ATM-dependent phosphorylation of nibrin in response to radiation exposure
It is demonstrated that nibrin is phosphorylated within one hour of treatment of cells with IR, and ATM physically interacts with and phosphorylatesnibrin on serine 343 both in vivo and in vitro.
ATM Activation and DNA Damage Response
Evidence is examined for the involvement of these various steps in ATM activation and attempt to put together a comprehensive picture of the overall process and its significance to DNA damage signalling.
The genetic defect in ataxia-telangiectasia.
The pleiotropic nature of the clinical and cellular phenotype suggests that the gene product involved is important in maintaining stability of the genome but also plays a more general role in signal transduction.
Robot-assisted laparoscopic prostatectomy versus open radical retropubic prostatectomy: early outcomes from a randomised controlled phase 3 study
Ataxia Telangiectasia Mutated (ATM) Signaling Network Is Modulated by a Novel Poly(ADP-ribose)-dependent Pathway in the Early Response to DNA-damaging Agents*
This study suggests that poly(ADP-ribose) might serve as a DNA damage sensory molecule that is critical for early DNA damage signaling, and demonstrates a functional and physical interaction between the major DSB signaling kinase, ATM and poly( ADP- ribose)ation by PARP-1, a key enzyme of chromatin remodeling.
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Findings show that BRCA1 is regulated by an ATM-dependent mechanism as a part of the cellular response to DNA damage, which argues in favor of the involvement of particular aspects of ATM function in breast cancer predisposition.