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Multicellular glial calcium waves may locally regulate neural activity or brain energetics. Here, we report a diffusion-driven astrocytic signal in the normal, intact brain that spans many astrocytic processes in a confined volume without fully encompassing any one cell. By using 2-photon microscopy in rodent cerebellar cortex labeled with fluorescent(More)
AIMS Exenatide has been demonstrated to improve glycaemic control in patients with type 2 diabetes, with no effect on heart rate corrected QT (QTc ) at therapeutic concentrations. This randomized, placebo- and positive-controlled, crossover, thorough QT study evaluated the effects of therapeutic and supratherapeutic exenatide concentrations on QTc . (More)
Many environmental data sets have a continuous domain, in time and/or space, and complex features that may be poorly modeled with a stationary Gaussian process (GP). We adapt stochastic volatility modeling to this context, resulting in a stochastic heteroscedastic process (SHP), which is unconditionally stationary and non-Gaussian. Conditional on a latent(More)
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