Elongation by Telomerase

Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
02419892017

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2015
2015
Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here… (More)
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2013
2013
Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3' G-rich overhangs. The overhang is generated by the… (More)
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Highly Cited
2007
Highly Cited
2007
In many organisms, telomeric DNA consists of long tracts of short repeats. Shorter tracts are preferentially lengthened by… (More)
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Highly Cited
2005
Highly Cited
2005
Telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 poly(ADP-ribosyl)ates TRF1 and… (More)
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Highly Cited
2005
Highly Cited
2005
The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is… (More)
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Highly Cited
2003
Highly Cited
2003
Mammalian telomeric DNA is mostly composed of double-stranded 5'-TTAGGG-3' repeats and ends with a single-stranded 3' overhang… (More)
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Highly Cited
2001
Highly Cited
2001
Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of… (More)
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Highly Cited
2000
Highly Cited
2000
Telomere elongation by telomerase balances the progressive shortening of chromosome ends due to the succession of replication… (More)
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Highly Cited
1997
Highly Cited
1997
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… (More)
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1989
1989
Telomeres stabilize chromosomal ends and allow their complete replication in vivo. In diverse eukaryotes, the essential telomeric… (More)
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