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Elongation by Telomerase

Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA… Expand
National Institutes of Health

Papers overview

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2016
2016
Telomere repeat factor 1 (TRF1) is a subunit of shelterin (also known as the telosome) and plays a critical role in inhibiting… Expand
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Review
2014
Review
2014
Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP… Expand
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2013
2013
Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3′ G-rich overhangs. The overhang is generated by the… Expand
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Highly Cited
2007
Highly Cited
2007
Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some of these molecules are present in the… Expand
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Highly Cited
2005
Highly Cited
2005
Heterogeneous nuclear ribonucleoprotein D, also known as AUF1, has two DNA/RNA-binding domains, each of which can specifically… Expand
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Highly Cited
2005
Highly Cited
2005
Telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 poly(ADP-ribosyl)ates TRF1 and… Expand
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Highly Cited
2005
Highly Cited
2005
The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is… Expand
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Highly Cited
2001
Highly Cited
2001
Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of… Expand
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Highly Cited
1997
Highly Cited
1997
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… Expand
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Highly Cited
1989
Highly Cited
1989
Telomeres stabilize chromosomal ends and allow their complete replication in vivo. In diverse eukaryotes, the essential telomeric… Expand
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