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Elongation by Telomerase

Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
02419892017

Related topics

Related topics

8 relations
Cell SurvivalDouble-Strand Break Repair Protein MRE11AMRE11A geneMRE11A wt Allele
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Related mentions per year

Related mentions per year

1943-2018
19401960198020002020
Elongation by Telomerase
Cell Survival
telomere
MRE11A gene
POT1 gene
MRE11A wt Allele

Papers overview

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2015
2015
Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis
Shelterin, a six-member complex, protects telomeres from nucleolytic attack and regulates their elongation by telomerase. Here… (More)
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2013
2013
CST for the grand finale of telomere replication.
Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3' G-rich overhangs. The overhang is generated by the… (More)
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Highly Cited
2007
Highly Cited
2007
Tel1p preferentially associates with short telomeres to stimulate their elongation.
In many organisms, telomeric DNA consists of long tracts of short repeats. Shorter tracts are preferentially lengthened by… (More)
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Highly Cited
2005
Highly Cited
2005
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 poly(ADP-ribosyl)ates TRF1 and… (More)
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Highly Cited
2005
Highly Cited
2005
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is… (More)
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Highly Cited
2003
Highly Cited
2003
Human POT1 Facilitates Telomere Elongation by Telomerase
Mammalian telomeric DNA is mostly composed of double-stranded 5'-TTAGGG-3' repeats and ends with a single-stranded 3' overhang… (More)
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Highly Cited
2001
Highly Cited
2001
Telomere maintenance by telomerase and by recombination can coexist in human cells.
Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of… (More)
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Highly Cited
2000
Highly Cited
2000
Cell cycle restriction of telomere elongation
Telomere elongation by telomerase balances the progressive shortening of chromosome ends due to the succession of replication… (More)
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Highly Cited
1997
Highly Cited
1997
Control of telomere length by the human telomeric protein TRF1
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… (More)
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1989
1989
Recognition and elongation of telomeres by telomerase.
Telomeres stabilize chromosomal ends and allow their complete replication in vivo. In diverse eukaryotes, the essential telomeric… (More)
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