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Elongation by Telomerase

Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA… Expand
National Institutes of Health

Related topics

Related topics

8 relations
Cell SurvivalDouble-Strand Break Repair Protein MRE11AMRE11A geneMRE11A wt Allele
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Crystal structure of a tankyrase 1-telomere repeat factor 1 complex.
Telomere repeat factor 1 (TRF1) is a subunit of shelterin (also known as the telosome) and plays a critical role in inhibiting… Expand
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Review
2014
Review
2014
Review of poly (ADP-ribose) polymerase (PARP) mechanisms of action and rationale for targeting in cancer and other diseases.
Poly (ADP-ribose) polymerases (PARPs) are a family of related enzymes that share the ability to catalyze the transfer of ADP… Expand
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2013
2013
CST for the grand finale of telomere replication
Telomeric DNA at eukaryotic chromosome ends terminates with single stranded 3′ G-rich overhangs. The overhang is generated by the… Expand
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Highly Cited
2007
Highly Cited
2007
Reevaluation of telomerase inhibition by quadruplex ligands and their mechanisms of action
Quadruplex ligands are often considered as telomerase inhibitors. Given the fact that some of these molecules are present in the… Expand
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Highly Cited
2005
Highly Cited
2005
Structure of hnRNP D Complexed with Single-stranded Telomere DNA and Unfolding of the Quadruplex by Heterogeneous Nuclear Ribonucleoprotein D*
Heterogeneous nuclear ribonucleoprotein D, also known as AUF1, has two DNA/RNA-binding domains, each of which can specifically… Expand
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Highly Cited
2005
Highly Cited
2005
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics.
Telomere elongation by telomerase is repressed in cis by the telomeric protein TRF1. Tankyrase 1 poly(ADP-ribosyl)ates TRF1 and… Expand
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Highly Cited
2005
Highly Cited
2005
Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro.
The POT1 (protection of telomeres 1) protein binds the ssDNA overhangs at the ends of chromosomes in diverse eukaryotes. POT1 is… Expand
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Highly Cited
2001
Highly Cited
2001
Telomere maintenance by telomerase and by recombination can coexist in human cells.
Immortal human cells maintain their telomeres by two independent mechanisms, a prevalent one dependent on de novo synthesis of… Expand
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Highly Cited
1997
Highly Cited
1997
Control of telomere length by the human telomeric protein TRF1
Human telomeres, the nucleoprotein complexes at chromosome ends, consist of tandem arrays of TTAGGG repeats bound to specific… Expand
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Highly Cited
1989
Highly Cited
1989
Recognition and elongation of telomeres by telomerase.
Telomeres stabilize chromosomal ends and allow their complete replication in vivo. In diverse eukaryotes, the essential telomeric… Expand
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