FAQ

Double-Strand Break Repair Protein MRE11A

Known as: Meiotic Recombination 11 Homolog A, MRE11 Homolog A, Endo/Exonuclease Mre11 
Double-strand break repair protein MRE11A (708 aa, ~81 kDa) is encoded by the human MRE11A gene. This protein plays a role in the mediation of DNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2005-2017
01220052017

Related topics

Related topics

9 relations
ATM Signaling PathwayDNA RepairDNA Repair GeneElongation by Telomerase
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Double-Strand Break Repair Protein MRE11A
DNA Repair
dna binding
Non-Homologous DNA End-Joining
Nucleoplasm
recombinational repair

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The MRE11-RAD50-NBS1 Complex Conducts the Orchestration of Damage Signaling and Outcomes to Stress in DNA Replication and Repair.
Genomic instability in disease and its fidelity in health depend on the DNA damage response (DDR), regulated in part from the… (More)
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2017
2017
Interaction of MRE11 and Clinicopathologic Characteristics in Recurrence of Breast Cancer: Individual and Cumulated Receiver Operating Characteristic Analyses
The interaction between the meiotic recombination 11 homolog A (MRE11) oncoprotein and breast cancer recurrence status remains… (More)
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2016
2016
Neutrophil sensing of cytoplasmic, pathogenic DNA in a cGAS–STING-independent manner
The innate immune system is an integral part of the host response to invading pathogens and endogenous danger signals. Pattern… (More)
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2015
2015
Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context
Etoposide (ETO), a drug used for the treatment of human tumors, is associated with the development of secondary malignancies… (More)
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2014
2014
DNA end resection is needed for the repair of complex lesions in G1-phase human cells.
Repair of DNA double strand breaks (DSBs) is influenced by the chemical complexity of the lesion. Clustered lesions (complex DSBs… (More)
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Highly Cited
2013
Highly Cited
2013
Microhomology-mediated End Joining and Homologous Recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells.
Microhomology-mediated end joining (MMEJ) is a major pathway for Ku-independent alternative nonhomologous end joining, which… (More)
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Highly Cited
2013
Highly Cited
2013
DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.
Double-stranded DNA (dsDNA) derived from pathogen- or host-damaged cells triggers innate immune responses when exposed to… (More)
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2011
2011
Genes Associated with Recurrence of Hepatocellular Carcinoma: Integrated Analysis by Gene Expression and Methylation Profiling
Gene expression is suppressed by DNA methylation. The goal of this study was to identify genes whose CpG site methylation and… (More)
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2005
2005
Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells.
AIM The genes were divided into seven categories according to biological function; apoptosis-related, immune response-related… (More)
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2005
2005
Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
re11–Rad50–Nbs1 (MRN) complex involvement in nonhomologous end joining (NHEJ) is controversial. The MRN complex is required for… (More)
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