MPTP Poisoning

Known as: MPTP Neurotoxicity Syndrome, MPTP-Induced Parkinsonism, Neurotoxicity Syndromes, MPTP 
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The anti-Parkinson monoamine oxidase (MAO)-B inhibitor rasagiline (Azilect) was shown to possess neuroprotective activities… (More)
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Highly Cited
2006
Highly Cited
2006
OBJECTIVE We investigated whether phosphatidylinositol 3-kinase (PI3K) might regulate mitochondrial permeability transition pore… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Brief periods of ischemia performed just at the time of reperfusion can reduce infarct size, a phenomenon called… (More)
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Highly Cited
2005
Highly Cited
2005
Trimetazidine (TMZ) affects mitochondrial function during ischemia. Mitochondrial permeability transition is a pivotal event in… (More)
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Highly Cited
1992
Highly Cited
1992
Computer imaging and immunohistochemical staining techniques were used to determine which midbrain dopaminergic (DA) cells are… (More)
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Highly Cited
1991
Highly Cited
1991
The goal of the study was to determine abnormalities in the spontaneous activity of globus pallidus neurons at the output of the… (More)
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Highly Cited
1991
Highly Cited
1991
Central to the neural mechanism of MPTP-induced parkinsonism is overactivity of the subthalamic nucleus. Lesion of the… (More)
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Highly Cited
1991
Highly Cited
1991
The mixed (D1 and D2) dopamine agonist apomorphine was injected (10-200 micrograms/kg, s.c.) to cynomolgus monkeys before and… (More)
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Highly Cited
1991
Highly Cited
1991
Deprenyl slows the progression of disabling symptoms in Parkinson's disease (PD) by an unknown mechanism. It can block the action… (More)
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Highly Cited
1984
Highly Cited
1984
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a neurotoxin which produces permanent parkinsonism in human and nonhuman… (More)
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