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MPTP Poisoning

Known as: MPTP Neurotoxicity Syndrome, MPTP-Induced Parkinsonism, Neurotoxicity Syndromes, MPTP 
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal dopaminergic neurons. Clinical features include… 
National Institutes of Health

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1-Methyl-4-phenylpyridiniumIn BloodMicrobiologicalchemically induced

Papers overview

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Highly Cited
2011
Highly Cited
2011
Early Presymptomatic and Long-Term Changes of Rest Activity Cycles and Cognitive Behavior in a MPTP-Monkey Model of Parkinson's Disease
Background It is increasingly recognized that non-motor symptoms are a prominent feature of Parkinson's disease and in the case… 
2007
2007
17β-Estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult
Highly Cited
2002
Highly Cited
2002
A novel in vivo post‐translational modification of p53 by PARP‐1 in MPTP‐induced parkinsonism
Sporadic Parkinson's disease (PD) affects primarily dopaminergic neurons of the substantia nigra pars compacta. There is evidence… 
Review
2001
Review
2001
Ubiquinone (Coenzyme Q10) and Mitochondria in Oxidative Stress of Parkinson’s Disease
Parkinson’s disease is the second most common neurodegenerative disorder after Alzheimer’s disease affecting approximately1% of… 
Highly Cited
1999
Highly Cited
1999
Cocaine reward and MPTP toxicity: alteration by regional variant dopamine transporter overexpression.
Review
1994
Review
1994
Antioxidant Mechanism and Protection of Nigral Neurons Against MPP+ Toxicity by Deprenyl (Selegiline)
The current research has demonstrated that MPP+ can induce lipid peroxidation in the nigrostriatal system of rat in vivo… 
Highly Cited
1994
Highly Cited
1994
Behavioral Effects of MPTP Administration in the Vervet Monkey
The neurotoxin l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces parkinsonian neurochemical and functional deficits in… 
Highly Cited
1990
Highly Cited
1990
6‐[18F]Fluoro‐L‐DOPA probes dopamine turnover rates in central dopaminergic structures
6‐[18F]Fluoro‐L‐DOPA (FDOPA) cerebral kinetics and metabolism were correlated in normal primates (Macaca nemestrina) and primates… 
Highly Cited
1987
Highly Cited
1987
Studies on the effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on central catecholamine neurons in C57 BL/6 mice. Comparison with three other strains of mice
Highly Cited
1987
Highly Cited
1987
Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism.
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