• Publications
  • Influence
Modifications of precentral cortex discharge and EMG activity in monkeys with MPTP-induced lesions of DA nigral neurons
TLDR
It is concluded that SN lesion leads to two main disturbances of cortical activity: i) the loss of the reciprocal pattern of response of movement-related cortical cells, and ii) an inability of the motor cortex to modify its activity in response to peripheral input.
Dopamine release in ventral striatum of pathological gamblers losing money
TLDR
Dopamine release in ventral striatum of pathological gamblers losing money is found to be higher in those with a gambling history than in those without a history of gambling.
Neurodegenerative Disease
  • D. Doudet
  • Biology
    Molecular Imaging and Biology
  • 2007
TLDR
This issue of Molecular Imaging and Biology aims at bringing together the current knowledge of neurodegenerative diseases gained from the use of in vivo, relatively noninvasive imaging technologies such as positron emission tomography (PET), single photon emission computed tomographic (SPECT), or magnetic resonance imaging (MRI).
MRI and PET studies of manganese‐intoxicated monkeys
TLDR
Results indicate that manganese intoxication is associated with preservation of the nigrostriatal dopaminergic pathway, despite clinical evidence of parkinsonian deficits, and is consistent with the demonstrated lack of therapeutic response to levodopa.
Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.
TLDR
In pathological gamblers dopamine release in the ventral striatum appears to be associated with increased excitement levels despite lower IGT performance, which might suggest a 'double deficit' function of dopamine in pathological gambling.
Increase in Dopamine Turnover Occurs Early in Parkinson's Disease: Evidence from a New Modeling Approach to PET 18F-Fluorodopa Data
TLDR
Results show that changes in EDV are measurable with PET earlier than changes in the dopamine synthesis and storage rate, indicating that EDV is a sensitive marker for early PD and that a dopamine turnover increase likely serves as an early compensatory mechanism.
A Reversible Tracer Analysis Approach to the Study of Effective Dopamine Turnover
TLDR
A new approach to the estimation of EDV based on reversible-tracer graphical methods that is proportional to the ratio of the distribution volumes of the specific uptake and precursor compartments and strongly validates the study of effective dopamine turnover.
Presynaptic dopaminergic deficits in Lesch-Nyhan disease.
TLDR
Patients with Lesch-Nyhan disease have abnormally few dopaminergic nerve terminals and cell bodies that appear to be developmental in origin, which suggests that they contribute to the characteristic neuropsychiatric manifestations of the disease.
6-18F-DOPA PET study in patients with schizophrenia
Inverse association between dopaminergic neurotransmission and Iowa Gambling Task performance in pathological gamblers and healthy controls.
TLDR
Investigation of dopamine release in the ventral striatum in relation to gambling performance on the Iowa Gambling Task showed that Pathological Gamblers with dopamine release had significantly lower IGT performance than Healthy Controls, and dopamine release was associated with significantly higher I GT performance in Healthy Controls and significantly lowerIGT performance in PathologicalGamblers.
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