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Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1–2 study
BACKGROUND MDV3100 is an androgen-receptor antagonist that blocks androgens from binding to the androgen receptor and prevents nuclear translocation and co-activator recruitment of theExpand
Tumor Treatment Response Based on Visual and Quantitative Changes in Global Tumor Glycolysis Using PET-FDG Imaging. The Visual Response Score and the Change in Total Lesion Glycolysis.
"Functional" tumor treatment response parameters have been developed to measure treatment induced biochemical changes in the entire tumor mass, using positron emission tomography (PET) and [F-18]Expand
Consensus recommendations for the use of 18F-FDG PET as an indicator of therapeutic response in patients in National Cancer Institute Trials.
1Cancer Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; 2Division of Nuclear Medicine, Huntsman Cancer Institute, University of Utah School of Medicine,Expand
Segmentation of lung lesion volume by adaptive positron emission tomography image thresholding
It is common protocol in radionuclide therapies to administer a tracer dose of a radiopharmaceutical, determine its lesion uptake and biodistribution by gamma imaging, and then use this informationExpand
Intensity of 18fluorodeoxyglucose uptake in positron emission tomography distinguishes between indolent and aggressive non-Hodgkin's lymphoma.
PURPOSE (18)Fluorodeoxyglucose positron emission tomography (FDG PET) is widely used for the staging of lymphoma. We investigated whether the intensity of tumor FDG uptake could differentiate betweenExpand
Circulating Tumor Cell Number and Prognosis in Progressive Castration-Resistant Prostate Cancer
Purpose: The development of tumor-specific markers to select targeted therapies and to assess clinical outcome remains a significant area of unmet need. We evaluated the association of baselineExpand
Genetically Targeted T Cells Eradicate Systemic Acute Lymphoblastic Leukemia Xenografts
Purpose: Human T cells targeted to the B cell–specific CD19 antigen through retroviral-mediated transfer of a chimeric antigen receptor (CAR), termed 19z1, have shown significant but partial in vivoExpand
Progress and Promise of FDG-PET Imaging for Cancer Patient Management and Oncologic Drug Development
2-[18F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) assesses a fundamental property of neoplasia, the Warburg effect. This molecular imaging technique offers a complementary approachExpand
Patterns of (18)F-FDG uptake in adipose tissue and muscle: a potential source of false-positives for PET.
UNLABELLED The routine use of PET/CT fusion imaging in a large oncology practice has led to the realization that (18)F-FDG uptake into normal fat and muscle can be a common source of potentiallyExpand
Selumetinib-enhanced radioiodine uptake in advanced thyroid cancer.
BACKGROUND Metastatic thyroid cancers that are refractory to radioiodine (iodine-131) are associated with a poor prognosis. In mouse models of thyroid cancer, selective mitogen-activated proteinExpand