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1-Methyl-4-phenylpyridinium

Known as: 1-Methyl-4-phenylpyridinium [Chemical/Ingredient], 1 Methyl 4 phenylpyridinium, N Methyl 4 phenylpyridine 
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of… Expand
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Increased autophagic vacuoles (AVs) occur in injured or degenerating neurons, under both developmental and pathological… Expand
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Highly Cited
2001
Highly Cited
2001
In the present study we demonstrate neuroprotective property of green tea extract and (–)‐epigallocatechin‐3‐gallate in N‐methyl… Expand
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Highly Cited
2000
Highly Cited
2000
Uptake of the Parkinsonism-inducing toxin, 1-methyl-4-phenylpyridinium (MPP+), into dopaminergic terminals is thought to block… Expand
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Highly Cited
1995
Highly Cited
1995
Mechanisms responsible for 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopamine (DA) neuronal death remain… Expand
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Highly Cited
1992
Highly Cited
1992
Abstract: Incubation of 10 mM I‐methyl‐4‐phenylpyridinium (MPP+) with sonicated beef heart mitochondria caused an irreversible… Expand
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Highly Cited
1988
Highly Cited
1988
In idiopathic Parkinson's disease massive cell death occurs in the dopamine-containing substantia nigra1,24. A link between the… Expand
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Highly Cited
1986
Highly Cited
1986
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), an impurity in certain batches of illicit heroin substitutes, is known to… Expand
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Highly Cited
1985
Highly Cited
1985
1-methyl-4-phenylpyridine (MPP+), a major metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP… Expand
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Highly Cited
1985
Highly Cited
1985
N-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuropathological and clinical abnormalities in humans, monkeys, and… Expand
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Highly Cited
1984
Highly Cited
1984
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a newly described neurotoxin which selectively destroys cells in the… Expand
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