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1-Methyl-4-phenylpyridinium

Known as: 1-Methyl-4-phenylpyridinium [Chemical/Ingredient], 1 Methyl 4 phenylpyridinium, N Methyl 4 phenylpyridine 
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The compound reduces dopamine levels, inhibits the biosynthesis of… 
National Institutes of Health

Related topics

Related topics

11 relations

Narrower (2)

1-Methyl-4-phenylpyridinium Chloride1-methyl-4-cyclohexylpyridinium

Broader (1)

Herbicides
In BloodMPTP Poisoningagonistsanalogs & derivatives

Papers overview

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Highly Cited
1999
Highly Cited
1999
Analysis of the neurotrophic effects of GPI-1046 on neuron survival and regeneration in culture and in vivo
Review
1998
Review
1998
Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.
Highly Cited
1995
Highly Cited
1995
Overexpression of Bcl-2 attenuates MPP+, but not 6-ODHA, induced cell death in a dopaminergic neuronal cell line
In order to investigate the role of Bcl-2 in dopaminergic cells, we established a dopaminergic neuronal cell line (MN9D) stably… 
Highly Cited
1994
Highly Cited
1994
Differential Cytotoxicities of N‐Methyl‐β‐Carbolinium Analogues of MPP+ in PC12 Cells: Insights into Potential Neurotoxicants in Parkinson's Disease
N‐Methylated β‐carbolinium cations that can form in vivo from environmental or endogenous β‐carbolines are putative neurotoxic… 
Highly Cited
1992
Highly Cited
1992
The extraneuronal transport mechanism for noradrenaline (uptake2) avidly transports 1-methyl-4-phenylpyridinium (MPP+)
SummaryThe corticosterone-sensitive extraneuronal transport mechanism for noradrenaline (uptake2) removes the neurotransmitter… 
Review
1991
Review
1991
A model of chronic neurotoxicity: long-term retention of the neurotoxin 1-methyl-4-phenylpyridinium (MPP+) within catecholaminergic neurons.
The mechanism by which 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces lesions in the nigrostriatal dopamine system… 
Highly Cited
1991
Highly Cited
1991
Epidermal Growth Factor Enhances Striatal Dopaminergic Parameters in the 1‐Methyl‐4‐Phenyl‐l, 2, 3, 6‐Tetrahydropyridine‐Treated Mouse
Intracerebroventricular infusion of epidermal growth factor (EOF) into mice with 1‐methyl‐4‐phenyl‐1, 2, 3, 6‐tetrahydropyridine… 
Highly Cited
1989
Highly Cited
1989
Striatal dopaminergic toxicity following intranigral injection in rats of 2-methyl-norharman, a β-carbolinium analog of N-methyl-4-phenylpyridinium ion (MPP+)
Highly Cited
1987
Highly Cited
1987
Quantitative autoradiography of brain binding sites for the vesicular acetylcholine transport blocker 2-(4-phenylpiperidino)cyclohexanol (AH5183).
2-(4-Phenylpiperidino)cyclohexanol (AH5183) is a noncompetitive and potent inhibitor of high-affinity acetylcholine transport… 
Highly Cited
1985
Highly Cited
1985
Reversible inhibition and mechanism-based irreversible inactivation of monoamine oxidases by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
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