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MLL wt Allele

Known as: KMT2A wt Allele, MLL1, WDSTS 
Human KMT2A wild-type allele is located in the vicinity of 11q23 and is approximately 89 kb in length. This allele, which encodes histone-lysine N… 
National Institutes of Health

Related topics

Related topics

11 relations
B Acute Lymphoblastic Leukemia with t(v;11q23); MLL RearrangedB Lymphoblastic Leukemia/Lymphoma with t(v;11q23); MLL RearrangedHematopoiesisInfant Acute Lymphoblastic Leukemia with MLL Rearrangement

Broader (1)

KMT2A gene

Papers overview

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2018
2018
A Novel Inducible Mouse Model of MLL-ENL-driven Mixed-lineage Acute Leukemia
Abstract Previous retroviral and knock-in approaches to model human t(11;19)+ acute mixed-lineage leukemia in mice resulted in… 
2017
2017
Preaxial polydactyly in an individual with Wiedemann‐Steiner syndrome caused by a novel nonsense mutation in KMT2A
Wiedemann‐Steiner syndrome (WDSTS) is an autosomal dominant disorder characterized by hypertrichosis, intellectual disability… 
Highly Cited
2011
Highly Cited
2011
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.
2009
2009
Low frequency of MLL3 mutations in colorectal carcinoma.
2005
2005
Cryptic MLL-AF10 fusion caused by insertion of duplicated 5' part of MLL into 10p12 in acute leukemia: a case report.
2004
2004
Diabetes (db/db) mutation-induced female reproductive tract hypercytolipidemia: estrogenic restoration of utero-ovarian indices.
Highly Cited
2001
Highly Cited
2001
An ins(X;11)(q24;q23) fuses the MLL and the Septin 6/KIAA0128 gene in an infant with AML‐M2
The MLL (HRX, ALL‐1 HTRX) gene at chromosome band 11q23 frequently is rearranged in acute lymphoblastic and myeloblastic leukemia… 
1997
1997
Multigenetic lesions in infant acute leukaemias: correlations with ALL‐1 gene status
In this study we investigated the presence of structural lesions in the ALL‐1, p53 and p16 (cyclin‐dependent kinase 4 inhibitor… 
Highly Cited
1995
Highly Cited
1995
ALL-1 gene rearrangements in acute myeloid leukemia: association with M4-M5 French-American-British classification subtypes and young age.
We have analyzed by Southern blotting the ALL-1 (MLL, HRX, Hrtx 1) gene configuration in a series of 126 patients with acute… 
1995
1995
Complex MLL rearrangement in a patient with T‐cell acute lymphoblastic leukemia
MLL (also known as ALL‐1, HTRX, or HRX) gene translocations are among the most common chromosomal abnormalities recognized in… 
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