MLL wt Allele

Known as: KMT2A wt Allele, MLL1, WDSTS 
Human KMT2A wild-type allele is located in the vicinity of 11q23 and is approximately 89 kb in length. This allele, which encodes histone-lysine N… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The… (More)
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Highly Cited
2006
Highly Cited
2006
Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4… (More)
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Review
2005
Review
2005
The marked association of abnormalities of chromosome 11 long arm, band q23, with human leukaemia led to the identification of… (More)
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Highly Cited
2004
Highly Cited
2004
Apoptosis contributes to myocardial ischemia/reperfusion (MI/R) injury, and both thioredoxin (Trx) and nitric oxide have been… (More)
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Highly Cited
2002
Highly Cited
2002
MLL (mixed lineage leukemia; also ALL-1 or HRX) is a proto-oncogene that is mutated in a variety of acute leukemias. Its product… (More)
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Highly Cited
2000
Highly Cited
2000
Many different chromosomal translocations occur in man at chromosome 11q23 in acute leukaemias. Molecular analyses revealed that… (More)
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Highly Cited
1999
Highly Cited
1999
One of the most common chromosomal abnormalities in acute leukemia is a reciprocal translocation involving the HRX gene (also… (More)
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Highly Cited
1994
Highly Cited
1994
Chromosome band 11q23, the location of the HRX gene, is a site of recurrent translocations in human malignancies. Infants with… (More)
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Highly Cited
1994
Highly Cited
1994
Rearrangements of the ALL-1 gene by reciprocal translocations involving chromosome band 11q23 are frequently associated with… (More)
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Highly Cited
1993
Highly Cited
1993
Chromosome band 11q23 is a site of recurrent translocations and interstitial deletions in human leukemias. Recent studies have… (More)
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