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Early signs of neuronal apoptosis in the substantia nigra pars compacta of the progressive neurodegenerative mouse 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid model of Parkinson’s disease
Morphometric evaluation of diabetes‐associated ovarian atrophy in the C57BL/KsJ mouse: Relationship to age and ovarian function
Ovarian dysfunction in the (db/db) mutant mouse is associated with follicular atrophy, adiposity, impaired steroidogenesis, and imbalanced glucose utilization, which occur in temporal association with the onset and progressive exacerbation of the hyperglycemic condition.
Diabetes (db/db) Mutation-Induced Ovarian Involution: Progressive Hypercytolipidemia
The cytological indications of cellular metabolic compromise, which precede the phenotypic expression of the DOS indices, suggests that correction of these abnormal shifts in ovarian endocrine and cellular metabolism may restore, delay, or prevent the further compromise of ovarian function by db/db mutation expression.
Cytochemical Analysis of Pancreatic Islet Lipoapoptosis: Hyperlipidemia-Induced Cytoinvolution following Expression of the Diabetes (db/db) Mutation
- D. Garris
- Biology, MedicinePathobiology
- 1 April 2005
The data suggest that the severity of progressive pancreatic lipoapoptosis disrupts regulatory cellular metabolic cascades, resulting in nuclear fragmentation, organelle dissolution and the subsequent promotion of a nonhomeostatic cytochemical milieu which ultimately renders islet B-cell populations susceptible to acinar proteolytic dissolution andgressive pancreatic involution.
Deciduoma formation in response to uterine trauma in the guinea pig.
Diurnal fluctuation of plasma cortisol levels in the guinea pig.
- D. Garris
- Biology, MedicineActa endocrinologica
- 1 April 1979
Data indicate that a diurnal fluctuation in plasma cortisol occurs in the guinea pig which is very reminiscent of that seen in the human and in contrast with that observed in the rat.
Intrauterine oxygen tension during the estrous cycle in the guinea pig: its relation to uterine blood volume and plasma estrogen and progesterone levels.
Synchronous changes in plasma ovarian steroid levels, uterine blood volume and intrauterine oxygen tension suggest that intraluminal oxygen concentration is regulated in part by estrogen and progesterone via alterations in uterine hemodynamics.
Age- and diabetes-associated alterations in regional brain norepinephrine concentrations and adrenergic receptor populations in C57BL/KsJ mice.
- D. Garris
- Biology, MedicineBrain research. Developmental brain research
- 1 February 1990
Estrogenic Stimulation of Hypothalamic-Limbic System Metabolism in Ageing Diabetic C57BL/KsJ Mice
- D. Garris
- Medicine, BiologyNeuroendocrinology
- 1 June 1999
The data demonstrate that the normal development-related decline in regional brain carbohydrate metabolism is accelerated by the diabetes syndrome, and that E therapy can modulate the syndrome-associated suppression of glucose utilization in steroid-sensitive CNS loci, and suggest that the depressive influences of the diabetes Syndrome on brain carbohydrate utilization rates may be therapeutically modified in recognized CNS regions possessing steroid-sequestering, metabolically responsive neurons.
Diabetes-associated endometrial disruption in the ketonuric, diabetic Chinese hamster.
The results of this study indicate that epithelial and stromal disruption are associated with the KD state in the Chinese hamster and are probably causally associated with reproductive failure.