KMT2A gene

Known as: LYSINE-SPECIFIC METHYLTRANSFERASE 2A, KMT2A, CXXC FINGER PROTEIN 7 
This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2017
02040608019802017

Papers overview

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Highly Cited
2009
Highly Cited
2009
Epigenetic mechanisms that maintain neurogenesis throughout adult life remain poorly understood. Trithorax group (trxG) and… (More)
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Highly Cited
2006
Highly Cited
2006
Histone H3 Lys4 (H3K4) methylation is a prevalent mark associated with transcription activation. A common feature of several H3K4… (More)
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Highly Cited
2005
Highly Cited
2005
A stable complex containing MLL1 and MOF has been immunoaffinity purified from a human cell line that stably expresses an epitope… (More)
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Highly Cited
2005
Highly Cited
2005
The mixed-lineage leukemia (MLL1/ALL-1/HRX) histone methyltransferase is involved in the epigenetic maintenance of… (More)
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Highly Cited
2003
Highly Cited
2003
Transcriptional deregulation through the production of dominant-acting chimeric transcription factors derived from chromosomal… (More)
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Highly Cited
2003
Highly Cited
2003
We recently found that MLL-rearranged acute lymphoblastic leukemias (MLL) have a unique gene expression profile including high… (More)
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Highly Cited
1998
Highly Cited
1998
The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal… (More)
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Highly Cited
1997
Highly Cited
1997
A subset of chromosomal translocations in acute leukemias results in the fusion of the trithorax-related protein HRX with a… (More)
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Highly Cited
1993
Highly Cited
1993
THE majority ( ∼ 75%) of infant acute leukaemias have a reciprocal translocation between chromosome 11q23 and one of several… (More)
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Highly Cited
1992
Highly Cited
1992
We have identified a human homolog of the Drosophila trithorax protein that is structurally altered by 11q23 translocations in… (More)
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