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KMT2A gene

Known as: LYSINE-SPECIFIC METHYLTRANSFERASE 2A, KMT2A, CXXC FINGER PROTEIN 7 
This gene is involved in transcriptional regulation and alterations in the gene are associated with acute lymphoblastic leukemia.
National Institutes of Health

Related topics

Related topics

20 relations
B Acute Lymphoblastic Leukemia with t(v;11q23); MLL RearrangedB Lymphoblastic Leukemia/Lymphoma with t(v;11q23); MLL RearrangedHematopoiesisInfant Acute Lymphoblastic Leukemia with MLL Rearrangement

Narrower (1)

MLL wt Allele

Broader (1)

SEPT6 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.
Highly Cited
2010
Highly Cited
2010
Regulation of H3K27me3 and H3K4me3 during early porcine embryonic development
The epigenetic marks H3K27me3 and H3K4me3 are important repressive and permissive histone modifications, respectively, which are… 
Highly Cited
2009
Highly Cited
2009
DDB1-CUL4 and MLL1 mediate oncogene-induced p16INK4a activation.
The induction of cellular senescence by oncogenic signals acts as a barrier to cellular transformation and is attained, in part… 
Highly Cited
2004
Highly Cited
2004
MLL fusion partners AF4 and AF9 interact at subnuclear foci
The MLL gene is involved in translocations associated with both acute lymphoblastic and acute myelogenous leukemia. These… 
Highly Cited
2003
Highly Cited
2003
Transcriptional activation is a key function encoded by MLL fusion partners
Chromosomal translocations that fuse the mixed lineage leukemia gene (MLL) to a variety of unrelated partner genes are frequent… 
Highly Cited
1999
Highly Cited
1999
The leukemogenic fusion of MLL with ENL creates a novel transcriptional transactivator
Translocations affecting the chromosomal locus 11q23 are hallmarks of infant leukemias. These events disrupt the MLL gene (also… 
Review
1999
Review
1999
Core-binding factor (CBF) and MLL-associated primary acute myeloid leukemia: biology and clinical implications
Abstract Presence of specific chromosomal abnormalities is one of the most important prognostic factors in acute myeloid leukemia… 
Highly Cited
1994
Highly Cited
1994
A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL.
Most of the translocations affecting the chromosome band 11q23, frequently seen in human acute leukemias, involve a restricted… 
Highly Cited
1993
Highly Cited
1993
Analysis of the murine All-1 gene reveals conserved domains with human ALL-1 and identifies a motif shared with DNA methyltransferases.
A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome… 
Highly Cited
1993
Highly Cited
1993
A serine/proline-rich protein is fused to HRX in t(4;11) acute leukemias.
Translocations involving chromosome band 11q23 in acute leukemias have recently been shown to involve the HRX gene that codes for… 
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