MERTK protein, human

Known as: proto-oncogene protein c-mer, human, Receptor Tyrosine Kinase MerTK, c-mer proto-oncogene protein, human 
Tyrosine-protein kinase Mer (999 aa, ~110 kDa) is encoded by the human MERTK gene. This protein is involved in ligand-dependent signaling.
National Institutes of Health

Papers overview

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2014
2014
Glioblastoma is an aggressive tumor that occurs in both adult and pediatric patients and is known for its invasive quality and… (More)
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Highly Cited
2013
Highly Cited
2013
To achieve its precise neural connectivity, the developing mammalian nervous system undergoes extensive activity-dependent… (More)
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Review
2013
Review
2013
MERTK is a receptor tyrosine kinase of the TAM (Tyro3, Axl, MERTK) family, with a defined spectrum of normal expression. However… (More)
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Highly Cited
2012
Highly Cited
2012
Phagocytosis of apoptotic cells and cellular debris is a critical process of maintaining tissue and immune homeostasis. Defects… (More)
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Highly Cited
2010
Highly Cited
2010
Tubby and tubby-like protein 1 (Tulp1) are newly identified phagocytosis ligands to facilitate retinal pigment epithelium (RPE… (More)
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Highly Cited
2008
Highly Cited
2008
Self-antigens expressed by apoptotic cells (ACs) may become targets for autoimmunity. Tolerance to these antigens is partly… (More)
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2008
2008
Apoptotic cells (AC) must be cleared by macrophages (Mø) to resolve inflammation effectively. Mertk and scavenger receptor A (SR… (More)
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Highly Cited
2007
Highly Cited
2007
Dendritic cells (DCs) play a key role in immune homeostasis and maintenance of self-tolerance. Tolerogenic DCs can be established… (More)
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2004
2004
PURPOSE Mutations in the MERTK gene are responsible for retinal degeneration in the Royal College of Surgeons (RCS) rat and are a… (More)
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Highly Cited
2000
Highly Cited
2000
Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis… (More)
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