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Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells.
Based on the DNA fragmentation profile in gel electrophoresis and the morphological changes in electron microscopy, the induction of apoptotic nuclear changes by mycotoxins and other microbialExpand
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Protosappanin A, a novel biphenyl compound from Sappan Lignum.
Protosappanin A (I), C15H12O5, mp 250-251°C, was isolated from the heart-wood of Caesalpinia sappan L. (appan Lignum). It yielded a triacetate (II) on acetylation, and an alcohol (III) on reductionExpand
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Azaphilones inhibit tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mice.
Monascorubrin (an azaphilone derivative) was isolated from Monascus anka, 'Monascus pigment', a natural pigment of food additivies, was extracted from Monasucs spp., and chaetoviridin A, one of theExpand
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Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G
Three new azaphilone derivatives designated falconensins E (5), F (6), and G (7) were isolated from the mycelium of Emericella falconensis, along with falconensins A (1), B (2), C (3), D (4), and HExpand
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New penicillide derivatives isolated from Penicillium simplicissimum
Two new penicillide derivatives, secopenicillides A (3) and B (4), were isolated along with penicillide (1) and purpactin A (2), and altenusin (5) and dehydroaltenusin (6), the antifungal substancesExpand
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Hydrogenated azaphilones from Emericella falconensis and E. fruticulosa
Abstract Six new hydrogenated azaphilones designated falconensins IN, and a new azaphilone, monomethyldihydromitorubrin, were isolated as minor components from mycelia of Emericella falconensisExpand
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Two chemotypes of Penicillium crustosum based on the analysis of indolic components
From the investigation of the indole metabolites of six strains of Penicillium crustosum isolated from foods in Tokyo in 1983-1984, it was clear that the tested strains were divided into twoExpand
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Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
Fifteen derivatives of falconensin were examined for their inhibitory activity against the induction of ear edema in mouse ear by application of 12-O-tetradecanoylphorbol-13-acetate (TPA). It wasExpand
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Structure and absolute configuration of emestrin, a new macrocyclic epidithiodioxopiperazine from Emericell striata
The structure elucidation of emestrin (1), a macrocyclic epidithioxopiperazine derivative isolated from the mycelial acetone extract of Emericella striata, is reported, based on its 1H and 13C n.m.r.Expand
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Two Novel Diarylheptanoid Glucosides from Myrica gale var. tomentosa and Absolute Structure of Plane-Chiral Galeon
From Myrica gale var. tomentosa, two new diarylheptanoids, myricatomentosides I and II, were isolated together with a plane-chiral diarylheptanoid, galeon. The absolute stereochemistry of (+)-galeonExpand
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