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Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells.
Investigation of the induction of apoptotic nuclear changes by mycotoxins and other microbial products in human promyelotic leukemia cells revealed that T-2 toxin induced the apoptosis at 10 ng/ml levels within 2-6 hr without significant cytotoxicity evaluated by the dye exclusion and MTT.
New penicillide derivatives isolated from Penicillium simplicissimum
Two new penicillide derivatives, secopenicillides A and B, were isolated from the extract of Penicillium simplicissimum IFM 53375, the antifungal substances of this fungus, by spectroscopic investigation and chemical correlation.
Protosappanin A, a novel biphenyl compound from Sappan Lignum.
Protosappanin A (I), C15H12O5, mp 250-251°C, was isolated from the heart-wood of Caesalpinia sappan L. (appan Lignum). It yielded a triacetate (II) on acetylation, and an alcohol (III) on reduction
Isolation and Structures of New Azaphilone Derivatives, Falconensins E-G, from Emericella falconensis and Absolute Configurations of Falconensins A-G
Three new azaphilone derivatives designated falconensins E (5), F (6), and G (7) were isolated from the mycelium of Emericella falconensis, along with falconensins A (1), B (2), C (3), D (4), and H
Inhibitory effects of falconensins on 12-O-tetradecanoylphorbol-13-acetate-induced inflammatory ear edema in mice
It was demonstrated that azaphilonoid falconensins exert inhibitory effects against TPA-induced inflammation in the ears of mice to a comparable degree as moascorubrin and indomethacin, which are known to have antitumor-promoting and anti-inflammatory effects.
Two chemotypes of Penicillium crustosum based on the analysis of indolic components
From the investigation of the indole metabolites of six strains of Penicillium crustosum isolated from foods in Tokyo in 1983-1984, it was clear that the tested strains were divided into two
A new pentanorlanostane derivative, cladosporide A, as a characteristic antifungal agent against Aspergillus fumigatus, isolated from Cladosporium sp.
The 4beta-aldehyde residue in 1 might be essential for the antifungal activity, since 23,24,25,26,27-pentanorlanost-8-ene-3beta,22-diol showed no inhibition against the above four fungi.
Antifungal substances against pathogenic fungi, talaroconvolutins, from talaromyces convolutus.
The dichloromethane extract of Talaromyces convolutus cultivated on barley exhibited antifungal activity against Candida albicans and four new tetramic acid derivatives, talaroconvolutins A, B, C, and D, were isolated along with ZG-1494alpha (5), and mitorubrin derivatives.
New citrinin derivatives isolated from Penicillium citrinum
Three new coupling compounds derived from citrinin (9) and 2,3,4-trimethyl-5,7-dihydroxy-2,3-dihydrobenzofuran (8) – penicitrinone A (1), penicitrinol A (2) and penicitrinone B (3) – and a new