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MCM4 protein, human

Known as: CDC21, CDC54, Cell Devision Cycle 21 Homolog 
DNA replication licensing factor MCM4 (863 aa, ~97 kDa) is encoded by the human MCM4 gene. This protein is involved in the initiation of DNA… 
National Institutes of Health

Related topics

Related topics

23 relations
ATP HydrolysisAdenosine TriphosphatasesCell CycleCell Cycle Control

Broader (1)

Minichromosome Maintenance Complex Component 4

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Over Expression of Minichromosome Maintenance Genes is Clinically Correlated to Cervical Carcinogenesis
Minichromosome Maintenance (MCM) proteins play important roles in cell cycle progression by mediating DNA replication initiation… 
Highly Cited
2006
Highly Cited
2006
Phosphorylation of MCM4 by Cdc7 Kinase Facilitates Its Interaction with Cdc45 on the Chromatin*♦
Cdc7 kinase, conserved from yeasts to human, plays important roles in DNA replication. However, the mechanisms by which it… 
Highly Cited
2003
Highly Cited
2003
Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiae.
The budding yeast Saccharomyces cerevisiae is unable to incorporate exogenous nucleosides into DNA. We have made a number of… 
Highly Cited
1996
Highly Cited
1996
Human replication proteins hCdc21, hCdc46 and P1Mcm3 bind chromatin uniformly before S-phase and are displaced locally during DNA replication.
Members of the Mcm-protein family have recently been shown to be involved in restricting DNA replication to a single cycle in… 
Highly Cited
1996
Highly Cited
1996
Binding of Human Minichromosome Maintenance Proteins with Histone H3*
Minichromosome maintenance (MCM) proteins play essential roles in eukaryotic DNA replication, but their biochemical properties… 
Highly Cited
1996
Highly Cited
1996
Phosphorylation of MCM4 by cdc2 protein kinase inhibits the activity of the minichromosome maintenance complex.
In eukaryotes, tight regulatory mechanisms ensure the ordered progression through the cell cycle phases. The mechanisms that… 
Highly Cited
1996
Highly Cited
1996
The ORC1 homolog orp1 in fission yeast plays a key role in regulating onset of S phase.
In a screen for new cell-cycle genes in Schizosaccharomyces pombe we have isolated cdc30, which is identical to orp1, a putative… 
Highly Cited
1996
Highly Cited
1996
Chromotin binding, nuclear localization and phosphorylation of Xenopus cdc21 are cell‐cycle dependent and associated with the control of initiation of DNA replication.
A Xenopus homologue of Schizosaccharomyces pombe cdc21 has been characterized as a new member of the MCM family of proteins. The… 
Highly Cited
1995
Highly Cited
1995
The nuclear envelope prevents reinitiation of replication by regulating the binding of MCM3 to chromatin in Xenopus egg extracts
Highly Cited
1987
Highly Cited
1987
The yeast DNA polymerase I transcript is regulated in both the mitotic cell cycle and in meiosis and is also induced after DNA damage
Using mitotic cultures synchronised by a feed-starve protocol or by elutriation, we have shown that the yeast DNA polymerase I… 
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