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Bub3 interaction with Mad2, Mad3 and Cdc20 is mediated by WD40 repeats and does not require intact kinetochores
- R. Fraschini, A. Beretta, L. Sironi, A. Musacchio, G. Lucchini, S. Piatti
- Biology, Computer ScienceThe EMBO journal
- 3 December 2001
It is suggested that Bub3 could serve as a platform for interactions between kinetochore checkpoint proteins, and its association with Mad2, Mad3 and Cdc20 might be instrumental for checkpoint activation.
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.
The findings suggest that Ddc2 may be the functional homolog of Schizosaccharomyces pombe Rad26, strengthening the hypothesis that the mechanisms leading to checkpoint activation are conserved throughout evolution.
Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells
By using gene editing to simultaneously introduce the CAR and disrupt TCR and CD52 in T cells, the authors generated functional CAR T cells that could evade host immunity for use in unmatched recipients and demonstrates the therapeutic potential of gene-editing technology.
The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends*
- M. Clerici, Davide Mantiero, G. Lucchini, M. Longhese
- BiologyJournal of Biological Chemistry
- 18 November 2005
Sae2 participates in DSB single strand annealing repair by ensuring both resection and intrachromosomal association of the broken ends, and SAE2 deletion slows down resection of an HO-induced DSB and impairs DSB end bridging.
The complete DNA sequence of yeast chromosome III
The entire DNA sequence of chromosome III of the yeast Saccharomyces cerevisiae has been determined. This is the first complete sequence analysis of an entire chromosome from any organism. The…
Budding Yeast Bub2 Is Localized at Spindle Pole Bodies and Activates the Mitotic Checkpoint via a Different Pathway from Mad2
The data suggest that activation of the mitotic checkpoint blocks progression through mitosis by independent and partially redundant mechanisms.
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication.
- M. Foiani, F. Marini, D. Gamba, G. Lucchini, P. Plevani
- BiologyMolecular and cellular biology
- 1 February 1994
The characterization of the temperature-sensitive pol12-T9 mutant allele demonstrates that the B subunit is required for in vivo DNA synthesis and correct progression through S phase, and reciprocal shift experiments indicate that the POL12 gene product plays an essential role at the early stage of chromosomal DNA replication, before the hydroxyurea-sensitive step.
The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation
- Enrico Baroni, V. Viscardi, H. Cartagena-Lirola, G. Lucchini, M. Longhese
- Biology, ChemistryMolecular and Cellular Biology
- 15 May 2004
The Saccharomyces cerevisiae Sae2 protein, known to be involved in processing meiotic and mitotic double-strand breaks, is required for proper recovery from checkpoint-mediated cell cycle arrest after DNA damage and is phosphorylated periodically during the unperturbed cell cycle and in response to DNA damage.
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks
It is shown that Saccharomyces cerevisiae Tel1, the ATM orthologue, has two functions in checkpoint response to DSBs, and evidence is provided that the kinetics of DSB resection can influence Tel1 activation, indicating that processing of the DSB termini might influence the transition from Tel1/ATM‐ to Mec1/ ATR‐dependent checkpoint.