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Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
The aim of this work is to contribute to the understanding of why certain types of mutations occur in people over a long period of time and to contribute towards the design of treatments for these diseases. Expand
BM28, a human member of the MCM2-3-5 family, is displaced from chromatin during DNA replication
A dramatic alteration in its nuclear binding during the cell cycle is reported and it is speculated that BM28 may be involved in the control that limits eukaryotic DNA replication to one round per cell cycle. Expand
G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus
It is shown that, in budding yeast, CDKs exclude the essential prereplicative-complex component Mcm4 from the nucleus, suggesting that G1 cyclins may diminish the cell’s capacity to assemble preReplicative complexes before B-type cyclins trigger origin firing during S phase. Expand
Characterization of fission yeast cohesin: essential anaphase proteolysis of Rad21 phosphorylated in the S phase.
Initial characterization of four putative cohesin subunits, Psm1, P sm3, Rad21, and Psc3, in fission yeast are reported, which are essential for sister chromatid cohesion. Expand
Chromatin binding of the fission yeast replication factor mcm4 occurs during anaphase and requires ORC and cdc18
In situ technique for studying the chromatin binding of proteins in the fission yeast Schizosaccharomyces pombe shows that mcm4 is required for re‐replication of the genome in the absence of mitosis and is associated with chromatin in cells undergoing re-replication. Expand
Fission yeast Cdc23/Mcm10 functions after pre-replicative complex formation to promote Cdc45 chromatin binding.
- J. Gregan, K. Lindner, +5 authors S. Kearsey
- Biology, Medicine
- Molecular biology of the cell
- 13 June 2003
The observations show that Cdc23/Mcm10 function is conserved between fission yeast and Xenopus, where in vitro analysis has indicated a similar requirement for Cdc45 binding, but apparently not compared with Saccharomyces cerevisiae, where Mcm10 is needed for Mcm2 chromatin binding. Expand
Nucleoplasmin cDNA sequence reveals polyglutamic acid tracts and a cluster of sequences homologous to putative nuclear localization signals.
- C. Dingwall, S. Dilworth, S. Black, S. Kearsey, L. Cox, R. Laskey
- Biology, Medicine
- The EMBO journal
- 1 January 1987
The isolated lambda gt11 phage containing nucleoplasmin cDNA is isolated and the sequence of the entire protein coding region of 200 amino acids for one of the two genes is determined. Expand
A panoply of errors: polymerase proofreading domain mutations in cancer
The current understanding of the mechanisms and consequences of polymerase proofreading domain mutations in human malignancies are summarized, and the potential utility of these variants as novel cancer biomarkers and therapeutic targets are highlighted. Expand
MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase…
It is shown that, although mitosis does indeed occur in the absence of replication if MCM proteins are degraded during G1-phase, anaphase is prevented if MCMs are degraded During S-phase and the data indicate that pre-RCs do not play a direct role in checkpoint control during chromosome replication. Expand
DNA damage induces Cdt1 proteolysis in fission yeast through a pathway dependent on Cdt2 and Ddb1
It is shown that in Schizosaccharomyces pombe, Cdt1 is proteolysed in M and G1 phases in response to DNA damage and that this mechanism seems to be conserved from yeast to Metazoa, indicating that it is independent of classicDNA damage and replication checkpoint pathways. Expand