Skip to search formSkip to main contentSkip to account menu

MAP3K13 protein, human

Known as: leucine zipper-bearing kinase protein, human, MLK, Mitogen-Activated Protein Kinase Kinase Kinase 13 
Mitogen-activated protein kinase kinase kinase 13 (966 aa, ~108 kDa) is encoded by the human MAP3K13 gene. This protein is involved in the mediation… 
National Institutes of Health

Related topics

Related topics

19 relations
CytoplasmEnzyme GeneMAP3K1 protein, humanMAP3K13 gene

Broader (1)

MAP Kinase Kinase Kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.
Highly Cited
2016
Highly Cited
2016
Mitochondrial Protein PGAM5 Regulates Mitophagic Protection against Cell Necroptosis
Necroptosis as a molecular program, rather than simply incidental cell death, was established by elucidating the roles of… 
Highly Cited
2015
Highly Cited
2015
Necroptosis is preceded by nuclear translocation of the signaling proteins that induce it
A signaling pathway that induces programmed necrotic cell death (necroptosis) was reported to be activated in cells by several… 
Highly Cited
2012
Highly Cited
2012
Staurosporine Induces Necroptotic Cell Death under Caspase-Compromised Conditions in U937 Cells
For a long time necrosis was thought to be an uncontrolled process but evidences recently have revealed that necrosis can also… 
Highly Cited
2011
Highly Cited
2011
DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
DLK is part of a specialized JNK signaling complex in axons that promotes apoptosis via c-Jun but axon degeneration via distinct… 
Highly Cited
2005
Highly Cited
2005
Neuroprotective Effects of Preconditioning Ischemia on Ischemic Brain Injury through Down-regulating Activation of JNK1/2 via N-Methyl-D-aspartate Receptor-mediated Akt1 Activation*
Our previous studies have demonstrated that the JNK signaling pathway plays an important role in ischemic brain injury and is… 
Highly Cited
2003
Highly Cited
2003
Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival*
Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates c-jun N-terminal kinase… 
Highly Cited
2002
Highly Cited
2002
NRAGE, a p75 Neurotrophin Receptor-interacting Protein, Induces Caspase Activation and Cell Death through a JNK-dependent Mitochondrial Pathway*
The p75 neurotrophin receptor (p75NTR) mediates signaling events leading to activation of the JNK pathway and cell death in a… 
Highly Cited
1999
Highly Cited
1999
The Dbl-related Protein, Lfc, Localizes to Microtubules and Mediates the Activation of Rac Signaling Pathways in Cells*
The possibility that the Dbl family member Lfc can activate Rac1 in cells is investigated in this study. Previously, we… 
Highly Cited
1996
Highly Cited
1996
Signaling from the Small GTP-binding Proteins Rac1 and Cdc42 to the c-Jun N-terminal Kinase/Stress-activated Protein Kinase Pathway
Certain small GTP-binding proteins control the enzymatic activity of a family of closely related serine-threonine kinases known… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)