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The TNF and TNF Receptor Superfamilies Integrating Mammalian Biology
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented.
Termination of autophagy and reformation of lysosomes regulated by mTOR
It is shown that mTOR signalling in rat kidney cells is inhibited during initiation of autophagy, but reactivated by prolonged starvation, and this generates proto-lysosomal tubules and vesicles that extrude from autolysosomes and ultimately mature into functional lysosomes, thereby restoring the full complement of lysosity in the cell.
CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation–mediated apoptosis of effector CD4+ T cells
It is shown that Treg cells induced apoptosis of effector CD4+ T cells in vitro and in vivo in a mouse model of inflammatory bowel disease and cytokine deprivation–induced apoptosis is a prominent mechanism by which T Reg cells inhibit effector T cell responses.
Regulation of an ATG7-beclin 1 Program of Autophagic Cell Death by Caspase-8
A new molecular pathway in which activation of the receptor-interacting protein (a serine-threonine kinase) and Jun amino-terminal kinase induced cell death with the morphology of autophagy is defined.
Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.
Immunological, cellular, and molecular evidence indicates that throughout the life of a T cell, apoptosis may be evoked in excessive, harmful, or useless clonotypes to preserve a healthy and balanced immune system.
Induction of apoptosis in mature T cells by tumour necrosis factor
- Lixin Zheng, G. Fisher, Robert E. Miller, J. Peschon, D. Lynch, M. Lenardo
- Biology, MedicineNature
- 28 September 1995
It is shown that tumour necrosis factor (TNF) can mediate mature T-cell receptor-induced apoptosis through the p75 TNF receptor and suggest that autoregulatory apoptosis of the mature T cells can occur by two distinct molecular mechanisms.
A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling.
A conserved domain in the extracellular region of the 60- and 80-kilodalton tumor necrosis factor receptors (TNFRs) was identified that mediates specific ligand-independent assembly of receptor…
Dominant interfering fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome
Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency
T cells from patients with heterozygous for three different germline, gain-of-function mutations in PIK3CD exhibited increased phosphorylation of the kinase Akt and hyperactivation of the metabolic checkpoint kinase mTOR, enhanced glucose uptake and terminal effector differentiation in vitro.