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Reactive oxygen species‐induced activation of ERK and p38 MAPK mediates PMA‐induced NETs release from human neutrophils
Neutrophils/polymorphonuclear leukocytes (PMNs), an important component of innate immune system, release extracellular traps (NETs) to eliminate invaded pathogens; however understanding of the roleExpand
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Negative Regulation of Mixed Lineage Kinase 3 by Protein Kinase B/AKT Leads to Cell Survival*
Mixed lineage kinase 3 (MLK3) is a mitogen-activated protein kinase kinase kinase (MAPKKK) that activates c-jun N-terminal kinase (JNK) and can induce cell death in neurons. By contrast, theExpand
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Neutrophil extracellular traps contain mitochondrial as well as nuclear DNA and exhibit inflammatory potential
Neutrophils expel extracellular traps (NETs) to entrap and exterminate the invaded micro‐organisms. Acute/chronic inflammatory disorders are often observed with aberrantly enhanced NETs formation andExpand
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Cytokines Induced Neutrophil Extracellular Traps Formation: Implication for the Inflammatory Disease Condition
Neutrophils (PMNs) and cytokines have a critical role to play in host defense and systemic inflammatory response syndrome (SIRS). Neutrophil extracellular traps (NETs) have been shown toExpand
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Increased myeloperoxidase enzyme activity in plasma is an indicator of inflammation and onset of sepsis.
INTRODUCTION Circulating lipopolysaccharides released from bacteria may activate both neutrophils and monocytes. The activated neutrophils release myeloperoxidase (MPO), a specific enzyme with strongExpand
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Macrophages: An elusive yet emerging therapeutic target of atherosclerosis
Macrophages are central to the initiation and progression of atherosclerosis and thus can be very appropriate targets for therapy. Cell adhesion molecules mediating monocytes recruitment to theExpand
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Nitric oxide donors release extracellular traps from human neutrophils by augmenting free radical generation.
High availability of NO, oxidative stress and neutrophil extracellular trap (NETs) contents are often noticed at the site of inflammation/infection. Studies from this lab and others have reported NOExpand
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Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis.
Extensive research on the mechanism of action and medicinal importance of curcumin obtained from turmeric (Curcuma longa) has unfolded its potential therapeutic value against many chronic ailments.Expand
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Nitrite content and antioxidant enzyme levels in the blood of schizophrenia patients
Abstract.Rationale: Recent studies have suggested augmentation in the inflammatory response as well as involvement of nitric oxide (NO) in mood disorders. Polymorphonuclear leukocytes (PMN), NO andExpand
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Platelet collagen receptors, signaling and antagonism: emerging approaches for the prevention of intravascular thrombosis.
Collagen, one of the major proteins of sub-endothelial vasculature get exposed following endothelium denudement, is a potent stimulator of platelet adhesion and aggregation. Adhesion of plateletsExpand
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