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Linkage Disequilibrium

Known as: LD, Disequilibrium, Linkage, Linkage Disequilibriums 
Nonrandom association of linked genes; the occurrence of some genes together, more often than would be expected based upon their physical separation… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (1)

Chromosome Mapping
Genetic screening methodfamily geneticshuman population geneticsphysiological aspects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2006
Review
2006
Major histocompatibility genes and ankylosing spondylitis.
  • J. Reveille
  • Baillière's Best Practice & Research : Clinical…
  • 2006
  • Corpus ID: 22176914
Highly Cited
2004
Highly Cited
2004
DOES LINKAGE DISEQUILIBRIUM GENERATE HETEROZYGOSITY‐FITNESS CORRELATIONS IN GREAT REED WARBLERS?
Abstract Heterozygosity‐fitness correlations (HFCs) at noncoding genetic markers are commonly assumed to reflect fitness effects… 
Highly Cited
2001
Highly Cited
2001
The genome-wide distribution of background linkage disequilibrium in a population isolate.
Recent interest in using association studies to investigate complex traits has focused attention on understanding linkage… 
Highly Cited
1999
Highly Cited
1999
Family-based association studies of bipolar disorder with candidate genes involved in dopamine neurotransmission: DBH, DAT1, COMT, DRD2, DRD3 and DRD5
The dopaminergic system has been implicated in the aetiology of mood disorders. We conducted family-based association studies for… 
Review
1998
Review
1998
A global survey of haplotype frequencies and linkage disequilibrium at the DRD2 locus
Abstract A four-site haplotype system at the dopamine D2 receptor locus (DRD2) has been studied in a global sample of 28 distinct… 
Highly Cited
1997
Highly Cited
1997
Genetic control of serum IgE levels and asthma: linkage and linkage disequilibrium studies in an isolated population.
Immunoglobulin E (IgE) concentration in serum is elevated in atopic diseases such as asthma. A large genomic region on chromosome… 
Highly Cited
1991
Highly Cited
1991
Detection of linkage disequilibrium between the myotonic dystrophy locus and a new polymorphic DNA marker.
We have examined the linkage of two new polymorphic DNA markers (D19S62 and D19S63) and a previously unreported polymorphism with… 
Highly Cited
1987
Highly Cited
1987
An ammo-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2
Phenylketonuria (PKU) is an autosomal recessive human genetic disorder caused by a deficiency of hepatic phenylalanine hydroxy… 
Highly Cited
1983
Highly Cited
1983
Restriction fragment length polymorphisms associated with immunoglobulin C gamma genes reveal linkage disequilibrium and genomic organization.
We have demonstrated that restriction fragment length polymorphisms (RFLPs) produced by BamHI can be used as markers for constant… 
Highly Cited
1977
Highly Cited
1977
Sjögren's Syndrome Associated with HLA-Dw3
Abstract Sjogren's syndrome is associated with a serologically defined histocompatibility antigen of the HLA-B locus, HLA-B8… 
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