• Publications
  • Influence
Genome-wide Association Analysis Identifies 14 New Risk Loci for Schizophrenia
Schizophrenia is an idiopathic mental disorder with a heritable component and a substantial public health impact. We conducted a multi-stage genome-wide association study (GWAS) for schizophreniaExpand
  • 1,179
  • 71
  • PDF
Gene ontology analysis of GWA study data sets provides insights into the biology of bipolar disorder.
We present a method for testing overrepresentation of biological pathways, indexed by gene-ontology terms, in lists of significant SNPs from genome-wide association studies. This method corrects forExpand
  • 394
  • 35
  • PDF
A mega-analysis of genome-wide association studies for major depressive disorder
Prior genome-wide association studies (GWAS) of major depressive disorder (MDD) have met with limited success. We sought to increase statistical power to detect disease loci by conducting a GWASExpand
  • 261
  • 14
  • PDF
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities. Recent studies have demonstrated a large overlap of genetic risk loci between these disorders butExpand
  • 279
  • 13
Genetics of affective (mood) disorders
The enormous public health importance of mood disorders, when considered alongside their substantial heritabilities, has stimulated much work, predominantly in bipolar disorder but increasingly inExpand
  • 219
  • 11
Rare copy number variants: a point of rarity in genetic risk for bipolar disorder and schizophrenia.
CONTEXT Recent studies suggest that copy number variation in the human genome is extensive and may play an important role in susceptibility to disease, including neuropsychiatric disorders such asExpand
  • 178
  • 11
  • PDF
Cognitive style in bipolar disorder.
BACKGROUND Abnormalities of cognitive style in bipolar disorder are of both clinical and theoretical importance. AIMS To compare cognitive style in people with affective disorders and in healthyExpand
  • 87
  • 11
  • PDF
Genomewide association studies: history, rationale, and prospects for psychiatric disorders.
OBJECTIVE The authors conducted a review of the history and empirical basis of genomewide association studies (GWAS), the rationale for GWAS of psychiatric disorders, results to date, limitations,Expand
  • 418
  • 10
  • PDF
Unrecognised bipolar disorder in primary care patients with depression.
BACKGROUND Bipolar disorder is complex and can be difficult to diagnose. It is often misdiagnosed as recurrent major depressive disorder. AIMS We had three main aims. To estimate the proportion ofExpand
  • 116
  • 10
  • PDF
Beating Bipolar: exploratory trial of a novel Internet-based psychoeducational treatment for bipolar disorder.
OBJECTIVES   Psychoeducational approaches are promising interventions for the long-term management of bipolar disorder. In consultation with professionals, patients, and their families we haveExpand
  • 85
  • 10