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Genetic Structure of Human Populations
We studied human population structure using genotypes at 377 autosomal microsatellite loci in 1056 individuals from 52 populations. Within-population differences among individuals account for 93 toExpand
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A Human Genome Diversity Cell Line Panel
A resource of 1064 cultured lymphoblastoid cell lines (LCLs) ([1][1]) from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation JeanExpand
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Evidence of positive selection acting at the human dopamine receptor D4 gene locus
  • Y. Ding, H. Chi, +9 authors R. Moyzis
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 26 December 2001
Associations have been reported of the seven-repeat (7R) allele of the human dopamine receptor D4 (DRD4) gene with both attention-deficit/hyperactivity disorder and the personality trait of noveltyExpand
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Evolutionary Dynamics of Human Toll-Like Receptors and Their Different Contributions to Host Defense
Infectious diseases have been paramount among the threats to health and survival throughout human evolutionary history. Natural selection is therefore expected to act strongly on host defense genes,Expand
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Insertional polymorphisms of full-length endogenous retroviruses in humans
Human endogenous retrovirus K (HERV-K) is distinctive among the retroviruses in the human genome in that many HERV-K proviruses were inserted into the human germline after the human and chimpanzeeExpand
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A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer risk.
Lung cancer is the leading cause of cancer deaths worldwide, yet few genetic markers of lung cancer risk useful for screening exist. The let-7 family-of-microRNAs (miRNA) are global geneticExpand
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The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
Abstract The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there isExpand
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The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus
Abstract The dopamine D4 receptor gene (DRD4) has an expressed polymorphism in the third exon that may have functional relevance. The polymorphism exists at two levels. At the higher level there isExpand
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Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles
BACKGROUND Catechol-O-methyltransferase (COMT) has been investigated as a candidate gene in many neurologic disorders involving catecholaminergic systems. The NlaIII restriction site polymorphismExpand
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Low nucleotide diversity in chimpanzees and bonobos.
Comparison of the levels of nucleotide diversity in humans and apes may provide much insight into the mechanisms of maintenance of DNA polymorphism and the demographic history of these organisms. InExpand
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