Limb Deformities, Congenital

Mammalian genomes are organized into megabase-scale topologically associated domains (TADs). We demonstrate that disruption of… (More)

Half a century ago, thalidomide was widely prescribed to pregnant women as a sedative but was found to be teratogenic, causing… (More)

Defects in cilia are associated with several human disorders, including Kartagener syndrome, polycystic kidney disease… (More)

Exogenous retinoic acid (RA) induces marked effects on limb patterning, but the precise role of endogenous RA in this process has… (More)

Unequivocal identification of the full composition of a gene is made difficult by the cryptic nature of regulatory elements… (More)

Preaxial polydactyly (PPD) is a common limb malformation in human. A number of polydactylous mouse mutants indicate that… (More)

Holt-Oram syndrome is one of the autosomal dominant human "heart-hand" disorders, with a combination of upper limb malformations… (More)

The cardiac homeobox protein Nkx2-5 is essential in cardiac development, and mutations in Csx (which encodes Nkx2-5) cause… (More)

Holt-Oram syndrome is characterized by upper limb malformations and cardiac septation defects. Here, we demonstrate that… (More)

In Drosophila, the trithorax-group and the Polycomb-group genes are necessary to maintain the expression of the homeobox genes in… (More)