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limb defects

Known as: defect limb, defects limbs, limb defect 
National Institutes of Health

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Limb Deformities, Congenital

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Thalidomide‐induced limb defects: resolving a 50‐year‐old puzzle
Despite the recent discovery that thalidomide causes limb defects by targeting highly angiogenic, immature blood vessels, several… 
Review
2008
Review
2008
Shedding light on an old mystery: Thalidomide suppresses survival pathways to induce limb defects
Many hypotheses have been proposed to explain the molecular mechanism of thalidomide teratogenicity, in particular regarding to… 
Highly Cited
2004
Highly Cited
2004
Regulation of limb development by the sphingosine 1-phosphate receptor S1p1/EDG-1 occurs via the hypoxia/VEGF axis.
Review
2002
Review
2002
Teratogen-induced limb defects.
  • L. Holmes
  • American journal of medical genetics
  • 2002
  • Corpus ID: 21532452
Limb abnormalities are one of the most common and visible phenotypic effects of several human teratogens. The specific effects… 
Highly Cited
2000
Highly Cited
2000
Maternal occupation in agriculture and risk of limb defects in Washington State, 1980-1993.
OBJECTIVES This study examined the association between maternal occupational exposure to agricultural chemicals and the risk of… 
Highly Cited
1995
Highly Cited
1995
Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring.
We investigated whether a woman's periconceptional use of a multivitamin containing folic acid was associated with a reduced risk… 
Highly Cited
1987
Highly Cited
1987
Limb body wall complex: I. Pathogenesis.
Twenty-five fetuses with limb body wall complex (LBW complex) were evaluated. The diagnosis was based on two out of three of the… 
Highly Cited
1987
Highly Cited
1987
Limb-body wall complex: II. Limb and spine defects.
Limb defects from 25 fetuses with limb-body wall (LBW) complex were evaluated to determine the mechanism of limb damage. The limb… 
Highly Cited
1983
Highly Cited
1983
Some teratogenic properties of ethanol and acetaldehyde in C57BL/6J mice: implications for the study of the fetal alcohol syndrome.
To investigate the teratogenic effect of acute alcohol exposure, pregnant C57BL/6J mice were exposed to 25% ethanol (either two… 
Highly Cited
1982
Highly Cited
1982
The classification and development of cadmium-induced limb defects in mice.
The aim of this study was to investigate the teratogenic action of cadmium (Cd) on the developing mouse limb. Pregnant mice… 
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