• Publications
  • Influence
Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies
TLDR
All the classes of blood pressure lowering drugs have a similar effect in reducing CHD events and stroke for a given reduction in blood pressure, indicating that the benefit is explained by blood pressure reduction itself.
Quantifying effect of statins on low density lipoprotein cholesterol, ischaemic heart disease, and stroke: systematic review and meta-analysis
TLDR
Statins can lower LDL cholesterol concentration by an average of 1.8 mmol/l which reduces the risk of IHD events by about 60% and stroke by 17% and is corroborated by results from the nine cohort studies.
A strategy to reduce cardiovascular disease by more than 80%
  • N. Wald, M. Law
  • Medicine
    BMJ : British Medical Journal
  • 25 June 2003
TLDR
The Polypill strategy could largely prevent heart attacks and stroke if taken by everyone aged 55 and older and everyone with existing cardiovascular disease and with widespread use would have a greater impact on the prevention of disease in the Western world than any other single intervention.
Randomized trial of preventive angioplasty in myocardial infarction.
TLDR
In patients with STEMI and multivessel coronary artery disease undergoing infarct-artery PCI, preventive PCI in noninfarct coronary arteries with major stenoses significantly reduced the risk of adverse cardiovascular events, as compared with PCI limited to the infarCT artery.
By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease?
TLDR
The results from the cohort studies, international comparisons, and clinical trials are remarkably consistent and estimate that a long term reduction in serum cholesterol concentration of 0.6 mmol/l (10%), which can be achieved by moderate dietary change,owers the risk of ischaemic heart disease by 50%" at age 40, falling to 20% at age 70.
First and second trimester antenatal screening for Down's syndrome: the results of the Serum, Urine and Ultrasound Screening Study (SURUSS).
The matching criteria were gestation (using an ultrasound crown–rump length or biparietal diameter measurement), duration of storage, and centre. Screening performance of the individual markers and
First-trimester or second-trimester screening, or both, for Down's syndrome.
TLDR
First-trimester combined screening at 11 weeks of gestation is better than second- Trimester quadruple screening but at 13 weeks has results similar to second- trimester quadruples screening.
Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials
TLDR
Combination low dose drug treatment increases efficacy and reduces adverse effects and three drugs at half standard dose are estimated to lower blood pressure and thereby reduce the risk of stroke by 63% and ischaemic heart disease events by 46% at age 60-69.
The accumulated evidence on lung cancer and environmental tobacco smoke
TLDR
The epidemiological and biochemical evidence on exposure to environmental Tobacco smoke, with the supporting evidence of tobacco specific carcinogens in the blood and urine of non-smokers exposed to environmental tobacco smoke, provides compelling confirmation that breathing other people's tobacco smoke is a cause of lung cancer.
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