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Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei
TLDR
These experiments show that for mammals, nuclei from terminally differentiated, adult somatic cells of known phenotype introduced into enucleated oocytes are capable of supporting full development. Expand
The catenin/cadherin adhesion system is localized in synaptic junctions bordering transmitter release zones
TLDR
It is found that two classes of cadherin-associated proteins, alpha N- and beta-catenin, are broadly distributed in adult brains, colocalizing with a synaptic marker, synaptophysin, and these proteins were localized in synaptic junctions of various types, forming a symmetrical adhesion structure. Expand
Shifts in cadherin profiles between human normal melanocytes and melanomas.
TLDR
The results suggest downregulation of E-cadherin but upregulation of N-c cadherin in melanoma cells, which may endow melanocytic cells with new adhesive properties and altered spatial relations that favor uncontrolled proliferation, migration, and invasion. Expand
Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion
TLDR
A novel mechanism for tumorigenesis in squamous epithelial cells is proposed; i.e., inadvertent expression of a nonepithelial cadherin by an epithelial cell is proposed. Expand
Human peroxisomal targeting signal-1 receptor restores peroxisomal protein import in cells from patients with fatal peroxisomal disorders
TLDR
The cloned and sequenced human cDNA homologue (PTS1R) of the Pichia pastoris PAS8 gene, the PTS1 receptor, represents the only case in which the molecular basis of the protein-import deficiency in human peroxisomal disorders is understood. Expand
Interaction of alpha-actinin with the cadherin/catenin cell-cell adhesion complex via alpha-catenin
TLDR
Evidence is presented that in fibroblasts alpha-actinin, but not vinculin, colocalizes extensively with the N-cadherin/catenin complex, and it is proposed that cadherin / catenin complexes are linked to the actin cytoskeleton via a direct association between alpha- actinin and alpha-caten in. Expand
Association of p120, a tyrosine kinase substrate, with E- cadherin/catenin complexes
TLDR
Immunocytological studies showed that p120 colocalized with E-cadherin at cell-cell contact sites, even after non-ionic detergent extraction, and thus, p120, whose function could be modulated by growth factors, may play a unique role in regulation of the cadherin- catenin adhesion system. Expand
Alternative processing of mRNAs encoding mammalian chromosomal high-mobility-group proteins HMG-I and HMG-Y.
TLDR
Evidence is presented that the 5'-untranslated-region and ORF heterogeneity of the cDNA clones is the result of alternative processing of RNA transcripts from a single functional gene. Expand
A major gene affecting age-related hearing loss is common to at least ten inbred strains of mice.
TLDR
It is shown that the same Chromosome 10 gene (Ahl) is a major contributor to AHL in nine other inbred mouse strains-129P1/ReJ, A/J, BALB/cByJ, BUB/BnJ, C57BR/cdJ, DBA/2J, NOD/LtJ, SKH2/j, and STOCK760. Expand
Neuronal ceroid lipofuscinosis (nclf), a new disorder of the mouse linked to chromosome 9.
TLDR
A second genetic variant of NCL is described in the mouse, neuronal ceroid lipofuscinosis, nclf, which exhibited a phenotype that was almost exactly the same as that observed in mnd/mnd mice. Expand
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